{"id":24241,"date":"2003-02-07T00:00:00","date_gmt":"2003-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonaje-y-caracterizacion-de-los-genes-cyp4b1-oatp1-y-oatp-d-nuevos-modelos-de-regulacion-androgenica-en-el-rinon-de-raton\/"},"modified":"2003-02-07T00:00:00","modified_gmt":"2003-02-07T00:00:00","slug":"clonaje-y-caracterizacion-de-los-genes-cyp4b1-oatp1-y-oatp-d-nuevos-modelos-de-regulacion-androgenica-en-el-rinon-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonaje-y-caracterizacion-de-los-genes-cyp4b1-oatp1-y-oatp-d-nuevos-modelos-de-regulacion-androgenica-en-el-rinon-de-raton\/","title":{"rendered":"Clonaje y caracterizaci\u00f3n de los genes cyp4b1, oatp1 y oatp-d: nuevos modelos de regulaci\u00f3n androg\u00e9nica en el ri\u00f1\u00f3n de rat\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joan Isern Marin <\/strong><\/h2>\n<p>Esta tesis se centra b\u00e1sicamente en el estudio y caracterizaci\u00f3n de tres genes murinos que comparten la caracter\u00edstica de expresarse y estar regulados por los andr\u00f3genos en el ri\u00f1\u00f3n, los cuales estimulan su expresi\u00f3n renal a nivel de mrna. El primero de ellos corresponde al gen cyp4b1 -representante de los citocromos p450, enzimas implicadas en el metabolismo oxidativo tanto de sustancias end\u00f3genas como en la detoxificaci\u00f3n de f\u00e1rmacos y xenobi\u00f3ticos. se ha estudiado su expresi\u00f3n en varios tejidos murinos y, mediante hibridaci\u00f3n in situ, localizado la distribuci\u00f3n de sus transcritos en el ri\u00f1\u00f3n. En este \u00faltimo tejido, tambi\u00e9n se ha investigado el efecto sobre su expresi\u00f3n de las hormonas andr\u00f3genas, utilizando ratones castrados y control de diferentes cepas. A nivel gen\u00f3mico, ha sido clonado el gen del cyp4b 1 as\u00ed como las dos primeras kb de promotor, determin\u00e1ndose su secuencia, su organizaci\u00f3n gen\u00f3mica y las intersecciones ex\u00f3n\/intr\u00f3n correspondientes. Con el fragmento de promotor aislado han sido preparadas diversas construcciones reporteras, con las cuales se han realizado ensayos de transfecci\u00f3n transitoria para evaluar los posibles elementos reguladores en el promotor, tanto a nivel de expresi\u00f3n basal en l\u00edneas renales, como a nivel de inducci\u00f3n y capacidad de respuesta androg\u00e9nica.  los dos genes restantes descritos -oatp1 y oatp-d\/mjam- eran previamente desconocidos, por lo cual se ha clonado y secuenciado su cdna entero a partir de ri\u00f1\u00f3n. Uno vez identificados los correspondientes cdnas, se ha visto que ambos correspond\u00edan a miembros de la familia murina de los transportadores de aniones org\u00e1nicos, oatps, prote\u00ednas poliespec\u00edficas de transporte con un amplio abanico de sustratos que pueden incluir desde sales biliares, esteroides conjudos y eicosanoides, hasta drogas y xenobi\u00f3ticos org\u00e1nicos. al igual que para el cyp4b1, se ha estudiado su distribuci\u00f3n tisular de ambos genes a nivel de mens<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonaje y caracterizaci\u00f3n de los genes cyp4b1, oatp1 y oatp-d: nuevos modelos de regulaci\u00f3n androg\u00e9nica en el ri\u00f1\u00f3n de rat\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonaje y caracterizaci\u00f3n de los genes cyp4b1, oatp1 y oatp-d: nuevos modelos de regulaci\u00f3n androg\u00e9nica en el ri\u00f1\u00f3n de rat\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joan Isern Marin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Messeguer Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: emili Itarte fresquet <\/li>\n<li>Jos\u00e9 Saez (vocal)<\/li>\n<li>Manuel Palac\u00edn prieto (vocal)<\/li>\n<li>Carlos Ciudad g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joan Isern Marin Esta tesis se centra b\u00e1sicamente en el estudio y caracterizaci\u00f3n de tres genes murinos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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