{"id":24261,"date":"2003-03-07T00:00:00","date_gmt":"2003-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptosis-y-mielodisplasia\/"},"modified":"2003-03-07T00:00:00","modified_gmt":"2003-03-07T00:00:00","slug":"apoptosis-y-mielodisplasia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/apoptosis-y-mielodisplasia\/","title":{"rendered":"Apoptosis y mielodisplasia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Fuertes N\u00fa\u00f1\u00e9z <\/strong><\/h2>\n<p>Hemos estudiado el \u00edndice apopt\u00f3tico mediante la t\u00e9cnica de tunel (tdt-mediated dutp nick-end labelling, as\u00ed como la expresi\u00f3n de las prote\u00ednas p53 y bcl-2 mediante procedimientos inmunohistoqu\u00edmicos, en muestras de biopsia de m\u00e9dula \u00f3sea (mo) de 103 personas: 61 pacientes diagnosticados de s\u00edndrome mielodispl\u00e1sico (smd) seg\u00fan los criterios del grupo fab (21 ar, 13 ars, 12 lmmc, 8 areb y 7 arebt) y dos grupos de control:  1,- 25 personas sanas, sin citopenias en la sangre perif\u00e9rica, mayores de 50 a\u00f1os.  2,- 17 pacientes diagnosticados de leucemia aguda mielobl\u00e1stica (lam) \u00abde novo\u00bb seg\u00fan los criterios del grupo fab.  hemos analizado la correlaci\u00f3n de estos par\u00e1metros con otras variables cl\u00ednico-biol\u00f3gicas de inter\u00e9s, as\u00ed como las variables que influyen sobre la supervivencia global de nuestro grupo de pacientes con smd.  el \u00edndice apopt\u00f3tico y las puntuaciones de p53 y de bcl-2 fueron significativamente mayores en los smd que en las personas sanas y en las lam que en los smd.  en los pacientes con smd no se observ\u00f3 ninguna correlaci\u00f3n estad\u00edsticamente significativa entre el \u00edndice apopt\u00f3tico, por un lado, y los recuentos celulares en la sangre perif\u00e9rica (sp) o el n\u00famero de l\u00edneas celulares dishemopoy\u00e9ticas en la mo, por otro. El \u00edndice apopt\u00f3tico tampoco influy\u00f3 de forma independiente en la superviviencia global de estos pacientes.  la puntuaci\u00f3n de bcl-2 no se correlacion\u00f3 con los recuentos en sp ni los hallazgos dishemopoy\u00e9ticos, ni influy\u00f3 en la supervivencia.  la puntuaci\u00f3n de p53 mostr\u00f3 una correlaci\u00f3n cordinal negativa con la concentraci\u00f3n de hemoglobina (r=-0,316, p=0,014; spearman) y con el recuento de lelucocitos (r=-0,274; p=0,034; spearman) en el grupo de pacientes con smd. Tambi\u00e9n demostr\u00f3 un valor pron\u00f3stico independiente para la supervivencia global en este trupo de pacientes (p=0,045; cox). La puntuaci\u00f3n de p53 es un par\u00e1metro de obtenci\u00f3n r\u00e1pida y sencilla que podr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apoptosis y mielodisplasia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apoptosis y mielodisplasia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Fuertes N\u00fa\u00f1\u00e9z <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Ramos Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cirilo Rozman borsmar <\/li>\n<li>carmen Burgaleta alonso de ozalla (vocal)<\/li>\n<li>f\u00e9lix Carbonell ram\u00f3n (vocal)<\/li>\n<li>guillermo Sanz santillana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Fuertes N\u00fa\u00f1\u00e9z Hemos estudiado el \u00edndice apopt\u00f3tico mediante la t\u00e9cnica de tunel (tdt-mediated dutp nick-end labelling, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[4430],"tags":[51971,197,39952,61336,71405,71404],"class_list":["post-24261","post","type-post","status-publish","format-standard","hentry","category-leon","tag-carmen-burgaleta-alonso-de-ozalla","tag-cirilo-rozman-borsmar","tag-felix-carbonell-ramon","tag-fernando-ramos-ortega","tag-guillermo-sanz-santillana","tag-marta-fuertes-nunez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24261"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24261\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}