{"id":24275,"date":"2003-03-07T00:00:00","date_gmt":"2003-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genomica-comparada-de-enzimas-rutas-metabolicas-y-redes-de-interaccion-de-protea%c2%adnas\/"},"modified":"2003-03-07T00:00:00","modified_gmt":"2003-03-07T00:00:00","slug":"genomica-comparada-de-enzimas-rutas-metabolicas-y-redes-de-interaccion-de-protea%c2%adnas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/genomica-comparada-de-enzimas-rutas-metabolicas-y-redes-de-interaccion-de-protea%c2%adnas\/","title":{"rendered":"Genomica comparada de enzimas, rutas metabolicas y redes de interacci\u00f3n de prote\u00ednas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Peregrin Alvarez Jos\u00e9 Manuel <\/strong><\/h2>\n<p>La evoluci\u00f3n de enzimas y rutas metab\u00f3licas ha sido objeto de intensos estudios. Sin embargo, hasta ahora estos trabajos previos s\u00f3lo se han centrado en un peque\u00f1o n\u00famero de familias de enzimas o rutas bioqu\u00edmicas. En la presente tesis se describe la distribuci\u00f3n filogen\u00e9tica de todo el complemento metab\u00f3lico conocido de escherichia coli, utilizando un m\u00e9todo basado en la comparaci\u00f3n de secuencias frente a bases de datos tax\u00f3n-espec\u00edficas. la mitad de las enzimas metab\u00f3licas tienen hom\u00f3logos en todos los dominios de la vida (archaea, bacteria y eucarya), representando familias involucradas en algunos de los procesos celulares m\u00e1s importantes. Con la presente tesis se demuestra, por primavera vez y de una forma exhaustiva, que el metabolismo se encuentra conservado a nivel de enzima. Adem\u00e1s, el presente an\u00e1lisis sugiere que a pesar  de la conservaci\u00f3n de las secuencias y de la extensa distribuci\u00f3n filogen\u00e9tica de las enzimas metab\u00f3licas, su agrupaci\u00f3n en rutas bioqu\u00edmicas es m\u00e1s variable de lo que previamente se pensaba.  por otro lado, descubrimos recientes en el an\u00e1lisis de genomas han mostrado que la predicci\u00f3n computacional de la funci\u00f3n de las prote\u00ednas en genomas completos no est\u00e1 limitada \u00fanicamente a los m\u00e9todos de homolog\u00eda de secuencias. los m\u00e9todos llamados \u00abgenome context\u00bb utilizan otra informaci\u00f3n de las secuencias de genomas completos para predecir la funci\u00f3n de una prote\u00edna. estas predicciones se obtienen mediante la detecci\u00f3n de la similitud existente entre pares de prote\u00ednas \u00abcomponentes\u00bb y prote\u00ednas \u00abcompuesto\u00bb (prote\u00ednas fusionadas). Puesto que la cantidad de prote\u00ednas \u00abcompuesto\u00bb se encuentra limitada en la naturaleza, hemos aumentado este conjunto de prote\u00ednas mediante la creaci\u00f3n de prote\u00ednas fusionadas \u00abartificialmente\u00bb a partir de pares de prote\u00ednas cuya interacci\u00f3n se ha demostrado experimentalmente. El objetivo es estudiar la extensi\u00f3n filogen\u00e9tica de las interaccione<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Genomica comparada de enzimas, rutas metabolicas y redes de interacci\u00f3n de prote\u00ednas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Genomica comparada de enzimas, rutas metabolicas y redes de interacci\u00f3n de prote\u00ednas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Peregrin Alvarez Jos\u00e9 Manuel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Chamber P\u00e9rez Manuel Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Palomares d\u00edaz <\/li>\n<li>a. Ouzounis christos (vocal)<\/li>\n<li>Antonio Mar\u00edn rodr\u00edguez (vocal)<\/li>\n<li>eloisa Pajuelo dominguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Peregrin Alvarez Jos\u00e9 Manuel La evoluci\u00f3n de enzimas y rutas metab\u00f3licas ha sido objeto de intensos estudios. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[71434,19792,4374,26457,71435,71433],"class_list":["post-24275","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-a-ouzounis-christos","tag-antonio-marin-rodriguez","tag-antonio-palomares-diaz","tag-chamber-perez-manuel-angel","tag-eloisa-pajuelo-dominguez","tag-peregrin-alvarez-jose-manuel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24275"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24275\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}