{"id":24283,"date":"2003-03-07T00:00:00","date_gmt":"2003-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-vascular-in-vitro-de-la-urocortina-influencia-del-sexo-y-efecto-de-la-diabetes\/"},"modified":"2003-03-07T00:00:00","modified_gmt":"2003-03-07T00:00:00","slug":"accion-vascular-in-vitro-de-la-urocortina-influencia-del-sexo-y-efecto-de-la-diabetes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/accion-vascular-in-vitro-de-la-urocortina-influencia-del-sexo-y-efecto-de-la-diabetes\/","title":{"rendered":"Acci\u00f3n vascular in vitro de la urocortina: influencia del sexo y efecto de la diabetes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Sanz Berzal <\/strong><\/h2>\n<p>La urocortina es un p\u00e9ptido relacionado con el factor de liberaci\u00f3n de corticotropina (crf) que puede intervenir en la regulaci\u00f3n cardiovascular. el objetivo de nuestro estudio fue analizar los efectos vasculares de la urocortina as\u00ed como la influencia del sexo y la repercusi\u00f3n de la diabetes mellitus en esos efectos. Para ello, se utilizaron arterias basilar, coronaria, caudal y renal de ratas machos y hembras, normogluc\u00e9micas y diab\u00e9ticas. las arterias se montaron en ba\u00f1os de \u00f3rganos para el registro de la tensi\u00f3n isom\u00e9trica, y la diabetes se indujo mediante inyecci\u00f3n intraperitoneal de estreptozotocina.  los resultados obtenidos fueron los siguientes:  1.- En los cuatro tipos de arterias con tensi\u00f3n basal, la urocortina (10 -12 -10 -8 m) no produjo ning\u00fan efecto, mientras que en los cuatro tipo de arterias con tono activo inducido con endotelina-1 (10 -9 -10 -8 m) este p\u00e9ptido produjo relajaci\u00f3n dependiente de la dosis.  2.- La relajaci\u00f3n producida por la urocortina fue similar en las arterias de ratas machos y hembras. Seg\u00fan los valores de la pd2, el orden de sensibilidad fue el siguiente: caudal&gt;renal=basilar&gt;coronaria para ambos sexos, y seg\u00fan el efecto m\u00e1ximo, el orden fue el siguiente: caudal&gt;renal=basilar&gt;coronaria tambi\u00e9n en ambos sexos.  3.- Con respecto a los mecanismos implicados en la relajaci\u00f3n producida pro la urocortina en las arterias renales de ratas hembras y machos observamos lo siguiente:  a.- En ambos sexos, la relajaci\u00f3n se bloqu\u00f3 con los antagonistas de los receptores crf (astresina y alfa-helical(9-41) y el bloqueante de los canales de potasio dependientes de calcio de alta conductancia (caribdotoxina), y no se modific\u00f3 con el inhibidor de la ciclooxigenasa (meclofenamato).  b.- En las ratas hembras, la relajaci\u00f3n se redujo con el inhibidor de la sintasa del \u00f3xido n\u00edtrico (l-name), con el inhibidor de adenilato ciclasa (sq22536), con el inhibidor de la protein kinasa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acci\u00f3n vascular in vitro de la urocortina: influencia del sexo y efecto de la diabetes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acci\u00f3n vascular in vitro de la urocortina: influencia del sexo y efecto de la diabetes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Sanz Berzal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Luis Garcia Villalon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Marco mart\u00ednez <\/li>\n<li>Juan  bautista Martinez leon (vocal)<\/li>\n<li>albino Garc\u00eda sacrist\u00e1n (vocal)<\/li>\n<li>Francisco Javier Salazar aparicio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Sanz Berzal La urocortina es un p\u00e9ptido relacionado con el factor de liberaci\u00f3n de corticotropina (crf) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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