{"id":24304,"date":"2003-04-07T00:00:00","date_gmt":"2003-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-tratamiento-hormonal-sustitutivo-en-la-menopausia-reactividad-vascular-papel-de-los-receptores-estrogenicos-y-del-oxido-na%c2%adtrico\/"},"modified":"2003-04-07T00:00:00","modified_gmt":"2003-04-07T00:00:00","slug":"efectos-del-tratamiento-hormonal-sustitutivo-en-la-menopausia-reactividad-vascular-papel-de-los-receptores-estrogenicos-y-del-oxido-na%c2%adtrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-del-tratamiento-hormonal-sustitutivo-en-la-menopausia-reactividad-vascular-papel-de-los-receptores-estrogenicos-y-del-oxido-na%c2%adtrico\/","title":{"rendered":"Efectos del tratamiento hormonal sustitutivo en la menopausia: reactividad vascular. papel de los receptores estrog\u00e9nicos y del \u00f3xido n\u00edtrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Sitges Carre\u00f1o <\/strong><\/h2>\n<p>La hip\u00f3tesis del proyecto es que el tratamiento con estr\u00f3genos mejora la reactividad vascular en pacientes postmenop\u00e1usicas con angina de pecho. este efecto se halla mediado por el \u00f3xido n\u00edtrico producido por la sintestasa del \u00f3xido endotelial (nos iii) y en este proceso intervienen los receptores estrog\u00e9nicos. Se realizaron estudios de funci\u00f3n endotelial a nivel de la circulaci\u00f3n coronaria y perif\u00e9rica de mujeres menop\u00e1usicas con angina, evaluando el efecto agudo y a medio plazo de la administraci\u00f3n de estradiol transd\u00e9rmico. Se observ\u00f3 que los estr\u00f3genos transd\u00e9rmicos mejoran la funci\u00f3n endotelial de las arterias coronarias y de la circulaci\u00f3n perif\u00e9rica, ya a las 24h del inicio del tratamiento y este beneficio se mantiene con un tratamiento m\u00e1s prolongada (6 semanas), a pesar de la administraci\u00f3n concomitante de progest\u00e1genos y de manera independiente del efecto sobre los l\u00edpidos. asimismo, se llev\u00f3 a cabo un estudio in vitro, utilizando c\u00e1maras de ba\u00f1os de \u00f3rganos, para evaluar el efecto del estradiol sobre la reactividad vascular de arterias mamarias internas de pacientes con aterosclerosis coronaria (fragmentos obtenidos durante la cirug\u00eda de revascularizaci\u00f3n coronaria) y para analizar el papel del \u00f3xido n\u00edtrico en ese efecto, observ\u00e1ndose que el estradiol produce in vitro un aumento en la vasodilataci\u00f3n endotelio-dependiente y que este efecto depende al menos en parte, de la disponibilidad de \u00f3xido n\u00edtrico. Por \u00faltimo, se evalu\u00f3 el efecto a corto plazo del estradiol transd\u00e9rmico sobre la expresi\u00f3n g\u00e9nica de la sintetasa del \u00f3xido n\u00edtrico y de los receptores estrog\u00e9nicos, determinada en muestras de arterias mamarias internas de pacientes con aterosclerosis coronaria (fragmentos obtenidos durante la cirug\u00eda de revascularizaci\u00f3n coronaria). Se evidenci\u00f3 que tras un tratamiento a corto plazo con estradiol transd\u00e9rmico, aumenta la expresi\u00f3n del arnm de la sintetasa del \u00f3xido n\u00edtrico end<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del tratamiento hormonal sustitutivo en la menopausia: reactividad vascular. papel de los receptores estrog\u00e9nicos y del \u00f3xido n\u00edtrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del tratamiento hormonal sustitutivo en la menopausia: reactividad vascular. papel de los receptores estrog\u00e9nicos y del \u00f3xido n\u00edtrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Sitges Carre\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gines Sanz Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: amadeo Betriu gibert <\/li>\n<li>angel Cquier fillat (vocal)<\/li>\n<li>Juan Balasch cortina (vocal)<\/li>\n<li>Mar\u00eda no Sent\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Sitges Carre\u00f1o La hip\u00f3tesis del proyecto es que el tratamiento con estr\u00f3genos mejora la reactividad vascular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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