{"id":24310,"date":"2003-04-07T00:00:00","date_gmt":"2003-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-protector-de-la-melatonina-en-un-modelo-experimental-de-isquemia-reperfusion-pancreatica\/"},"modified":"2003-04-07T00:00:00","modified_gmt":"2003-04-07T00:00:00","slug":"papel-protector-de-la-melatonina-en-un-modelo-experimental-de-isquemia-reperfusion-pancreatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-protector-de-la-melatonina-en-un-modelo-experimental-de-isquemia-reperfusion-pancreatica\/","title":{"rendered":"Papel protector de la melatonina en un modelo experimental de isquemia-reperfusi\u00f3n pancre\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Jose Mu\u00f1oz Casares <\/strong><\/h2>\n<p>El modelo de isquemia-reperfusi\u00f3n pancre\u00e1tica realizado se ha caracterizado por un incremento del estr\u00e9s oxidativo con una elevada producci\u00f3n de radicales libres de ox\u00edgeno, expresada por un aumento de lipoper\u00f3xidos y una disminuci\u00f3n de glutati\u00f3n reducido, as\u00ed como una depleci\u00f3n de los enzimas antioxidantes en la gl\u00e1ndula pancre\u00e1tica.  desde el punto de vista bioqu\u00edmico, la isquemia-reperfusi\u00f3n pancre\u00e1tica se ha asociado a un descenso en la producci\u00f3n de insulina y una elevaci\u00f3n en los niveles plasm\u00e1ticos de las enzimas pancre\u00e1ticas exocrinas.  las lesiones histopatol\u00f3gicas observadas en el modelo experimental de isquemia-reperfusi\u00f3n pancre\u00e1tica variaron seg\u00fan el momento evolutivo: a las 24 horas predominaron el edema glandular y la aparici\u00f3n de fen\u00f3menos de apoptosis. A las 48 horas de producida la isquemia y posterior reperfusi\u00f3n no se observaron lesiones apopt\u00f3sicas, predominado los fen\u00f3menos de necrosis de la gl\u00e1ndula pancre\u00e1tica.  de forma global, la administraci\u00f3n de melatonina tanto aplicada de forma previa a la isquemia prancre\u00e1tica como una vez producida esta, e inmediatamente tras la fase de reperfusi\u00f3n, determin\u00f3 una mejora de los par\u00e1metros de estr\u00e9s oxidativo y funci\u00f3n glandular, as\u00ed como una recuperaci\u00f3n de las lesiones observadas en el estudio histopatol\u00f3gico. Analizando los diferentes momentos de aplicaci\u00f3n de la melatonina, se observaron mejores resultados con la doble dosis, administraci\u00f3n pre y postisquemia, en la cual no solo se recuperaron los par\u00e1metros de estr\u00e9s oxidativo y la funci\u00f3n glandular, sino que se evit\u00f3 la aparici\u00f3n de lesiones histopatol\u00f3gicas de la gl\u00e1ndula pancre\u00e1tica en la mayor\u00eda de los animales tratados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel protector de la melatonina en un modelo experimental de isquemia-reperfusi\u00f3n pancre\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel protector de la melatonina en un modelo experimental de isquemia-reperfusi\u00f3n pancre\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Jose Mu\u00f1oz Casares <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Padillo Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Pera madrazo <\/li>\n<li>Jos\u00e9 Mar\u00eda Garcia gil (vocal)<\/li>\n<li>guillermo Solorzano peck (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Ortega bevia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Jose Mu\u00f1oz Casares El modelo de isquemia-reperfusi\u00f3n pancre\u00e1tica realizado se ha caracterizado por un incremento del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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