{"id":24353,"date":"2003-04-07T00:00:00","date_gmt":"2003-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/n-acetil-l-glutamato-quinasa-de-escherichia-coli-estructura-tridimensional-e-implicaciones-funcionales\/"},"modified":"2003-04-07T00:00:00","modified_gmt":"2003-04-07T00:00:00","slug":"n-acetil-l-glutamato-quinasa-de-escherichia-coli-estructura-tridimensional-e-implicaciones-funcionales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/n-acetil-l-glutamato-quinasa-de-escherichia-coli-estructura-tridimensional-e-implicaciones-funcionales\/","title":{"rendered":"N-acetil-l-glutamato quinasa de escherichia coli: estructura tridimensional e implicaciones funcionales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Gil Ortiz <\/strong><\/h2>\n<p>Esta tesis versa sobre el enzima n-acetil-l-glutamano quinasa (nagk), no regulado por asquina, de escherichia coli. Este enzima, miembro de la familia amino\u00e1cido quinasa, cataliza la transferencia del fosfato gamma del atp al acetilglutomato en el segundo paso de la s\u00edntesis de argimina. En el desarrollo de esta tesis doctoral hemos determinado por medio de cristalograf\u00eda de rayos x la estructura tridimensional de este enzima a una resoluci\u00f3n de 1.5 a, que ha revelado que se trata de un homod\u00edmero, con subunidades de 258 amino\u00e1cidos, nucleado por una hoja beta molecular abierta de 16 elementos, rodeada por alfa h\u00e9lices. Adem\u00e1s, hemos caracterizado los sitios de uni\u00f3n para los dos sustratos, hemos concluido que la cat\u00e1lisis se lleva a cabo a trav\u00e9s de un mecanismo de tipo asociativo y hemos definido por medio de varios complejos cristalinos el curso de fosf\u00f3rido durante la reacci\u00f3n. Tambi\u00e9n se describe la uni\u00f3n superficial de una segunda mol\u00e9cula de nucle\u00f3tido y se avanza hac\u00eda el conocimiento de la regulaci\u00f3n por retroalimentaci\u00f3n de la fosforilaci\u00f3n de acetilglutamato mediante la cristalizaci\u00f3n de la nagk regulada por argimina de pseudomonas aeruginosa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>N-acetil-l-glutamato quinasa de escherichia coli: estructura tridimensional e implicaciones funcionales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 N-acetil-l-glutamato quinasa de escherichia coli: estructura tridimensional e implicaciones funcionales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Gil Ortiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Rubio Zamora<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepci\u00f3n Abad mazario <\/li>\n<li>Carlos G\u00f3mez-moreno calera (vocal)<\/li>\n<li>ignacio Fita rodriguez (vocal)<\/li>\n<li>Jos\u00e9 Manuel Gonzalez ros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Gil Ortiz Esta tesis versa sobre el enzima n-acetil-l-glutamano quinasa (nagk), no regulado por asquina, de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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