{"id":24367,"date":"2003-04-07T00:00:00","date_gmt":"2003-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tratamiento-con-irinotecan-oxaliplatino-y-5-fluorouracilo-en-combinacion-en-pacientes-con-carcinoma-colorrectal-metastasico\/"},"modified":"2003-04-07T00:00:00","modified_gmt":"2003-04-07T00:00:00","slug":"tratamiento-con-irinotecan-oxaliplatino-y-5-fluorouracilo-en-combinacion-en-pacientes-con-carcinoma-colorrectal-metastasico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/tratamiento-con-irinotecan-oxaliplatino-y-5-fluorouracilo-en-combinacion-en-pacientes-con-carcinoma-colorrectal-metastasico\/","title":{"rendered":"Tratamiento con irinotecan, oxaliplatino y 5-fluorouracilo en combinaci\u00f3n, en pacientes con carcinoma colorrectal metast\u00e1sico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Emiliano Calvo Aller <\/strong><\/h2>\n<p>El oxaliplatino, el irinotecan y el 5-fu (modulado con leucovorin) son los agentes m\u00e1s activos contra el carcinoma colorrectal metast\u00e1sico (ccm), tienen diferentes mecanismos de acci\u00f3n, actividad sin\u00e9rgica cuando se combinan, y diferente perfil de toxicidad que permite su combinaci\u00f3n sin reducci\u00f3n significativa de sus dosis individuales. Hoy se considera como tratamiento est\u00e1ndar la combinaci\u00f3n doble de 5-fu\/leucovorin con oxaliplatino o con irinotecan. Por ello, la triple combinaci\u00f3n de estos agentes se perfila como un tratamiento innovador, original, y de gran inter\u00e9s, que se ha analizado tanto desde el punto de vista de su factibilidad, en un estudio piloto de 53 pacientes, como de su tolerancia y eficacia, en un estudio fase ii con 26 pacientes.  adicionalmente, como segunda hip\u00f3tesis de trabajo, se ha evaluado la posible afectaci\u00f3n del \u00edndice biliar del irinotecan (par\u00e1metro que refleja su eliminaci\u00f3n biliar y que se correlaciona con la diarrea t\u00f3xica del citost\u00e1tico) por la aplicaci\u00f3n intraarterial hep\u00e1tica del 5-fu a los pacientes con enfermedad fundamentalmente hep\u00e1tica del estudio piloto inicial, habida cuenta su potencial toxicidad hepato-biliar.  se concluye que:  1,- la combinaci\u00f3n de oxaliplatino 120 mg\/m2 d\u00eda 1, irinotecan 250 mg\/m2 d\u00eda 1, y 5-fu 2.6 gr\/m2 con leucovorin 500 mg\/m2 d\u00edas 1 y 15, cada 4 semanas, administrados de forma endovenosa, es muy activa y aceptablemente tolerada en el tratamiento de pacientes con carcinoma colorrectal metast\u00e1sico.  2,- este r\u00e9gimen merece ser investigado en estudios fase iii, en comparaci\u00f3n con los reg\u00edmenes de quimioterapia est\u00e1ndar actual.  3,- la administraci\u00f3n del 5-fluorouracilo por v\u00eda hep\u00e1tica y del irinotecan a una dosis de 300 mg\/m2 dentro de este triplete, produce toxicidad severa.  4,- la administraci\u00f3n intraarterial hep\u00e1tica del 5-fu, con respecto a su infusi\u00f3n endovenosa, no interfiere en la inactivaci\u00f3n y eliminaci\u00f3n hep\u00e1tica del<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tratamiento con irinotecan, oxaliplatino y 5-fluorouracilo en combinaci\u00f3n, en pacientes con carcinoma colorrectal metast\u00e1sico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tratamiento con irinotecan, oxaliplatino y 5-fluorouracilo en combinaci\u00f3n, en pacientes con carcinoma colorrectal metast\u00e1sico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Emiliano Calvo Aller <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar Fernandez Hidalgo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jeronimo Forteza vila <\/li>\n<li> Vieitez de prado Jos\u00e9 m. (vocal)<\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Emiliano Calvo Aller El oxaliplatino, el irinotecan y el 5-fu (modulado con leucovorin) son los agentes m\u00e1s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[71631,2937,53895,18372,71632,71633],"class_list":["post-24367","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-emiliano-calvo-aller","tag-jeronimo-forteza-vila","tag-jesus-garcia-foncillas-lopez","tag-jorge-augusto-quiroga-vilas","tag-oscar-fernandez-hidalgo","tag-vieitez-de-prado-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24367"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24367\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}