{"id":24420,"date":"2003-07-07T00:00:00","date_gmt":"2003-07-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-de-deflazacort-en-conejo-efecto-ahorrador-inducido-por-eritromicina\/"},"modified":"2003-07-07T00:00:00","modified_gmt":"2003-07-07T00:00:00","slug":"farmacocinetica-de-deflazacort-en-conejo-efecto-ahorrador-inducido-por-eritromicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/farmacocinetica-de-deflazacort-en-conejo-efecto-ahorrador-inducido-por-eritromicina\/","title":{"rendered":"Farmacocinetica de deflazacort en conejo: efecto ahorrador inducido por eritromicina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Escudero Pastor <\/strong><\/h2>\n<p>Se ha estudiado el comportamiento farmacocin\u00e9tico del deflazacort en el conejo, tras su administraci\u00f3n por v\u00eda intravenosa y oral, a la dosis de 5 mg\/kg. Adem\u00e1s, se ha considerado, para ambos casos, las condiciones experimentales basales, y despu\u00e9s de 10 d\u00edas de tratamientos con 75 mg\/kg\/12 h de eritromicina.  el trabajo se ha llevado a cabo un doble prop\u00f3sito:  1,- establecer los par\u00e1metros farmacocin\u00e9ticos del glucocorticoide en la especie animal mencionada.  2,- detectar la existencia o no de efecto ahorrador de esteroides por parte del antibi\u00f3tico macr\u00f3lido seleccinado.  as\u00ed pues, se ha efectuado un estudio cruzado con 6 animales de la especie ya referida. La determinaci\u00f3n de los niveles plasm\u00e1ticos de 21-hidroxi-deflazacort se ha realizado mediante hplc (bernareggi et al., 1987) y el ajuste farmacocin\u00e9tico con los programas pkcalc (shumaker, 1986) y multi (yamaoka et al.,1986). para discernir el modelo farmacocin\u00e9tico m\u00e1s adecuado, se ha utilizado el criterio de informaci\u00f3n de akaike (aic) y el coeficiente de correlaci\u00f3n (corr.).  en la especie animal considerada, la distribuci\u00f3n del glucocorticoide se ha desarrollado seg\u00fan un modelo bicompartimental abierto, al ser administrado por v\u00eda intravenosa, y seg\u00fan un modelo monocompartimental cuando se ha administrado por v\u00eda oral. Dichos resultados se han observado tanto en las condiciones basales como tras pretratamiento con estearato de eritromicina.  los par\u00e1metros farmacocin\u00e9ticos obtenidos para el deflazacort han presentado diferencias estad\u00edsticamente significativas entre la situaci\u00f3n basal y posteritromicina. Dichas variaciones son abribuibles al efecto ahorrador de esteroides del antibi\u00f3tico macr\u00f3lido utilizado para el presente trabajo, e indicar\u00edan que se ha producido una interacci\u00f3n de tipo farmacocin\u00e9tico.  la absorci\u00f3n del deflazacort por v\u00eda oral ha sido r\u00e1pida aunque se ha prolongado tras la administraci\u00f3n eritromicina. Finalmente, l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica de deflazacort en conejo: efecto ahorrador inducido por eritromicina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica de deflazacort en conejo: efecto ahorrador inducido por eritromicina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Escudero Pastor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elisa Escudero Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Brugger auban arturo jose <\/li>\n<li> Serrano caballero Juan  Manuel (vocal)<\/li>\n<li> Miguel zamora m. teresa san (vocal)<\/li>\n<li>Francisco Cuello gijon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Escudero Pastor Se ha estudiado el comportamiento farmacocin\u00e9tico del deflazacort en el conejo, tras su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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