{"id":24541,"date":"2003-10-07T00:00:00","date_gmt":"2003-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enzima-convertidora-de-la-angiotensina-endotelinas-glicoproteina-p-e-hipoxia-pulmonar-estudio-experimental\/"},"modified":"2003-10-07T00:00:00","modified_gmt":"2003-10-07T00:00:00","slug":"enzima-convertidora-de-la-angiotensina-endotelinas-glicoproteina-p-e-hipoxia-pulmonar-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enzima-convertidora-de-la-angiotensina-endotelinas-glicoproteina-p-e-hipoxia-pulmonar-estudio-experimental\/","title":{"rendered":"Enzima convertidora de la angiotensina, endotelinas, glicoproteina p e hipoxia pulmonar. estudio experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leopoldo Mu\u00f1oz Medina <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivos  se plantea la hip\u00f3tesis de trabajo al comprobar que en las situaciones cl\u00ednicas de reagudizaci\u00f3n de enfermedades pulmonares cr\u00f3nicas se produc\u00eda un aumento de la ta que volv\u00eda a situaci\u00f3n basal tras controlar la reagudizaci\u00f3n de la enfermedad.  materiales y m\u00e9todos  de este modo y tras validar un modelo experimental de insuficiencia respiratoria, con inhalaci\u00f3n de talco, se tomaron 16 animales de experimentaci\u00f3n, ratas adultas winstar de la cepa nestl\u00e9 que se dividieron en dos grupos, uno basal y otro simetido a talcosis durante dos semanas \/ (2,5 horas al d\u00eda, 6 d\u00edas a la semana).  se determinaron en suero, po2, pco2, ph, eca y aldosterona y en homogeneizado pulmonar eca, et-1, et-3 y expresi\u00f3n del gen de la glicoprote\u00edna p.  resultados  se obtuvieron resultados estad\u00edsticamente significativos en la comparaci\u00f3n de medias de todos los valores excepto la pco2, ph y et-1 se establecieron correlaciones signficativas de signo positivo entre la po2 y la ecap, pco2 con la adldosterona s\u00e9rica y la et-3 y entre la aldosterona s\u00e9rica y la et-3 y la glicoprote\u00edan p. Tambi\u00e9n con la et-3 y et-1. Se observaron correlaciones significativas de signo negativo entre po2 con ecas y et-3, ecap con aldosterona s\u00e9rica, ecas y et-3.  conclusiones  tras el an\u00e1lisis de los resultados obtenidos y revisando la bibliograf\u00eda al respecto se concluy\u00f3.  1,- tras la lesi\u00f3n pulmonar e insuficiencia respiratoria inducida, aparece un significativo incremento en los niveles de eca sangu\u00edneos y a\u00fan m\u00e1s marcado de la aldosterona s\u00e9rica, con una deficiente correlaci\u00f3n entre ellos, estos ascensos podr\u00edan explicar un posible incremento de la presi\u00f3n arterial.  2,- la hipoxemia se correlacion\u00f3 con el incremento sangu\u00edneo de la eca, pero no con el ascenso de la aldosterona, sugiriendo la existencia de un mecanismo sobre a\u00f1adido, a la a-ii, en la producci\u00f3n de aldosterona durante la insuficiencia respira<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enzima convertidora de la angiotensina, endotelinas, glicoproteina p e hipoxia pulmonar. estudio experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enzima convertidora de la angiotensina, endotelinas, glicoproteina p e hipoxia pulmonar. estudio experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leopoldo Mu\u00f1oz Medina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Miras Parra Fco. Julio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Aneiros cachaza <\/li>\n<li> Callejas rubio Jos\u00e9 Luis (vocal)<\/li>\n<li>agust\u00edn Mart\u00edn moreno (vocal)<\/li>\n<li>alicia Conde valero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leopoldo Mu\u00f1oz Medina Introducci\u00f3n y objetivos se plantea la hip\u00f3tesis de trabajo al comprobar que en las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[72047,54970,72046,35731,72045,4273],"class_list":["post-24541","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-agustin-martin-moreno","tag-alicia-conde-valero","tag-callejas-rubio-jose-luis","tag-jose-aneiros-cachaza","tag-leopoldo-munoz-medina","tag-miras-parra-fco-julio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24541"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24541\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}