{"id":24551,"date":"2003-10-07T00:00:00","date_gmt":"2003-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vip-y-pacap-potenciales-agentes-terapeuticos-en-enfermedades-inflamatorias-autoinmunes\/"},"modified":"2003-10-07T00:00:00","modified_gmt":"2003-10-07T00:00:00","slug":"vip-y-pacap-potenciales-agentes-terapeuticos-en-enfermedades-inflamatorias-autoinmunes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/vip-y-pacap-potenciales-agentes-terapeuticos-en-enfermedades-inflamatorias-autoinmunes\/","title":{"rendered":"Vip y pacap, potenciales agentes terap\u00e9uticos en enfermedades inflamatorias\/autoinmunes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Catalina Abad Rabat <\/strong><\/h2>\n<p>Los tres sistemas que controlan la homeostasis del organismo (nervioso, endocrino e inmunol\u00f3gico) se encuentra interconectados. As\u00ed, el n\u00famero de neurop\u00e9ptidos que se expresan y act\u00faan en el sistema inmunol\u00f3gico es cada vez mayor. Entre ellos se encuentran vip (p\u00e9ptido intestinal vasoactivo) y pacap (p\u00e9ptido activador de la adenilato ciclasa pituitaria), que siendo p\u00e9ptidos antiinflamatorios, juegan un papel muy importante en el sistema inmunol\u00f3gico. Recientemente, se ha descubierto su capacidad moduladora de la respuesta de los linfocitos t colaboradores, polarizando su producci\u00f3n de citoquinas hacia th2 (inhibiendo la th1). Por ello, vip y pacap son candidatos para el tratamiento de enfermedades inflamatorias como el choque s\u00e9ptico y de enfermedades autoinmunes inflamatorias con una respuesta th1 como la artritis reumatoide o la enfermedad de crohn. Los objetivos de esta tesis fueron profundizar en el papel de vip y pacap en los modelos murinos de choque endot\u00f3xico, artritis reumatoide y enfermedad de crohn, adem\u00e1s de estudiar la producci\u00f3n de pacap por c\u00e9lulas del sistema inmunol\u00f3gico. los resultados demuestran en primer lugar que pacap, es producido por los linfocitos de \u00f3rganos linfoides al igual que vip, apoyando la existencia de una or\u00edgen com\u00fan de sus genes por duplicaci\u00f3n de un gen ancestral. Adem\u00e1s, vip y pacap resultaron tener efectos beneficioso en todos los modelos de enfermedades inflamatorias estudiadas. En el caso del choque s\u00e9ptico, vip y pacap juegan un papel protector, actuando principalmente a trav\u00e9s del receptor vpac1 pero parcialmente a trav\u00e9s del receptor pac1 a trav\u00e9s de la inhibici\u00f3n de la producci\u00f3n de la interleuquina 6. Adem\u00e1s, vip y pacap fueron efectivos como agentes terap\u00e9uticos en el tratamiento de los modelos murinos de artritis reumatoide y enfermedad de crohn, reduciendo los par\u00e1metros moleculares de estas enfermedades y por tanto su sintomatolog\u00eda cl\u00ednica. finalmente, vip<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vip y pacap, potenciales agentes terap\u00e9uticos en enfermedades inflamatorias\/autoinmunes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vip y pacap, potenciales agentes terap\u00e9uticos en enfermedades inflamatorias\/autoinmunes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Catalina Abad Rabat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa P\u00e9rez Gomariz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li>nieves Rodr\u00edguez henche (vocal)<\/li>\n<li>Juan  Carlos Prieto villap\u00fan (vocal)<\/li>\n<li>Juan  ram\u00f3n Calvo guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Catalina Abad Rabat Los tres sistemas que controlan la homeostasis del organismo (nervioso, endocrino e inmunol\u00f3gico) se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[3237,72070,17527,10892,72072,72071],"class_list":["post-24551","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-benjamin-fernandez-ruiz","tag-catalina-abad-rabat","tag-juan-carlos-prieto-villapun","tag-juan-ramon-calvo-gutierrez","tag-nieves-rodriguez-henche","tag-rosa-perez-gomariz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24551"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24551\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}