{"id":24577,"date":"2003-10-07T00:00:00","date_gmt":"2003-10-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-neurofisiologicos-de-la-alodinia-producida-por-inflamacion-papel-de-las-interacciones-presinapticas-entre-mecanorreceptores-y-nociceptores\/"},"modified":"2003-10-07T00:00:00","modified_gmt":"2003-10-07T00:00:00","slug":"mecanismos-neurofisiologicos-de-la-alodinia-producida-por-inflamacion-papel-de-las-interacciones-presinapticas-entre-mecanorreceptores-y-nociceptores","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/mecanismos-neurofisiologicos-de-la-alodinia-producida-por-inflamacion-papel-de-las-interacciones-presinapticas-entre-mecanorreceptores-y-nociceptores\/","title":{"rendered":"Mecanismos neurofisiol\u00f3gicos de la alodinia producida por inflamaci\u00f3n: papel de las interacciones presin\u00e1pticas entre mecanorreceptores y nociceptores"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Garc\u00eda Nicas <\/strong><\/h2>\n<p>La hiperalgesia es un incremento de las respuestas a est\u00edmulos que son normalmente dolorosos. La hiperalgesia producida pro una lesi\u00f3n en la piel abarca dos zonas conc\u00e9ntricas: la zona que rodea el lugar de la lesi\u00f3n (hiperalgesia primaria) y la zona que se extiende m\u00e1s all\u00e1 de la zona lesionada incorporando zonas no afectadas por la lesi\u00f3n (hiperalgesia secundaria). existen muchas evidencias que apoyan que los cambios que tienen lugar en la hiperalgesia primaria son el resultado de la sensibilizaci\u00f3n de los nociceptores cut\u00e1neos y por tanto puede explicarse en t\u00e9rminos de sensibilizaci\u00f3n perif\u00e9rica. Sin embargo, la hiperalgesia secundaria no puede explicarse simplemente por cambios perif\u00e9ricos sino que debe ser atribuida a variaciones en el procesamiento  central de las se\u00f1ales generadas en los mecanorreceptores de bajo umbral lo que produce dolor evocado por tacto, o alodinia, y el aumento de la sensibilidad dolorosa mec\u00e1nica, o hiperalgesia.  la lesi\u00f3n producida en la piel no solo produce la sensibilizaci\u00f3n de los nociceptores sino que tambi\u00e9n cambia las propiedades de las neuronas espinales, las cuales no solo reflejan el aumento de actividad inducida en los nociceptores perif\u00e9ricos sino que tambi\u00e9n contribuyen a generar alteraciones funcionales intr\u00edsecas de las redes neuronales espinales. Estas alteraciones se agrupan bajo el nombre gen\u00e9rico de \u00absensibilizaci\u00f3n central\u00bb. Los dos fen\u00f3menos que constituyen las caracter\u00edsticas sensoriales de la hiperalgesia secundaria, alodina e hiperalgesia mec\u00e1nica, requieren componentes centrales cuyos mecanismos neurofisiol\u00f3gicos todav\u00eda se ignoran en gran parte aunque todos los modelos actuales de hiperalgesia y alodinia est\u00e1n basados en la idea de \u00absensibilizaci\u00f3n central\u00bb.  en esta tesis se han investigado los mecanismos centrales espinales de la alodina inducida por agentes irritantes aplicados a al piel. Nos hemos basado en la hip\u00f3tesis de interacci\u00f3n presin\u00e1pt<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos neurofisiol\u00f3gicos de la alodinia producida por inflamaci\u00f3n: papel de las interacciones presin\u00e1pticas entre mecanorreceptores y nociceptores<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos neurofisiol\u00f3gicos de la alodinia producida por inflamaci\u00f3n: papel de las interacciones presin\u00e1pticas entre mecanorreceptores y nociceptores <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Garc\u00eda Nicas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Cerver\u00f3 Santiago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Fuentes cubero <\/li>\n<li> Pozao Garc\u00eda Miguel \u00e1ngel (vocal)<\/li>\n<li>Jos\u00e9 Manuel Baeyens cabrera (vocal)<\/li>\n<li>elvira De la pe\u00f1a garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Garc\u00eda Nicas La hiperalgesia es un incremento de las respuestas a est\u00edmulos que son normalmente dolorosos. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426],"tags":[72129,72127,6040,23352,13221,72128],"class_list":["post-24577","post","type-post","status-publish","format-standard","hentry","category-alcala","tag-elvira-de-la-pena-garcia","tag-esther-garcia-nicas","tag-fernando-cervero-santiago","tag-jose-angel-fuentes-cubero","tag-jose-manuel-baeyens-cabrera","tag-pozao-garcia-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24577"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24577\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}