{"id":24597,"date":"2003-11-07T00:00:00","date_gmt":"2003-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/busqueda-de-nuevas-dianas-terapeuticas-en-el-ictus-isquemico-factor-de-necrosis-tumoral-y-su-papel-en-la-tolerancia-isquemica-cerebral-humana\/"},"modified":"2003-11-07T00:00:00","modified_gmt":"2003-11-07T00:00:00","slug":"busqueda-de-nuevas-dianas-terapeuticas-en-el-ictus-isquemico-factor-de-necrosis-tumoral-y-su-papel-en-la-tolerancia-isquemica-cerebral-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/busqueda-de-nuevas-dianas-terapeuticas-en-el-ictus-isquemico-factor-de-necrosis-tumoral-y-su-papel-en-la-tolerancia-isquemica-cerebral-humana\/","title":{"rendered":"B\u00fasqueda de nuevas dianas terap\u00e9uticas en el ictus isqu\u00e9mico: factor de necrosis tumoral y su papel en la tolerancia isqu\u00e9mica cerebral humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Blanco Gonzalez <\/strong><\/h2>\n<p>Antecedentes y objetivos  trabajos previos han demostrado la presencia de tolerancia isqu\u00e9mica en pacientes con ictus isqu\u00e9micos precedidos por accidentes isqu\u00e9micos transitorios (ait) ipsilaterales, pero por ahora el mecanismo no es bien conocido. Nuestro objetivo es averiguar el papel del factor de necrosis tumoral alfa (tnf-alfa) y la interleukina 6 (il-6) en um modelo cl\u00ednico de tolerancia isqu\u00e9mica.  m\u00e9todo  estudiamos 283 pacientes con ictus isqu\u00e9mico hemisf\u00e9rico con menos de 24 horas de evoluci\u00f3n. Definimos ait como episodio transitorio de isquemia de menos de 1 hora de duraci\u00f3n y seleccionando aquellos que ocurren en las 72 horas previas a un infarto definitivo. El volumen final de infarto se calcul\u00f3 en la tac realizada entre el 4\u00c2\u00ba y 7\u00c2\u00ba d\u00eda. Se defini\u00f3 mal pron\u00f3stico como muerte o una puntuaci\u00f3n en la escala de barther por debajo de 85 puntos a los 3 meses. La concentraci\u00f3n de tnf-alfa e il-6 fue media en una muestra de plasma obtenida al ingreso. Definimos una nueva variable que llamamos factor bioqu\u00edmico de tolerancia isqu\u00e9mica como la presencia de valores de tnf-alfa por encima de 30 pg\/ml y de il-6 por debajo de 30 pg\/ml (fbt).  resultados  en 38 (13,4%) pacientes se recogi\u00f3 el antecedentes de ait ipsilateral en las 72 horas previas a un ictus isqu\u00e9mico hemisf\u00e9ricos. En este grupo se observ\u00f3 menor proporci\u00f3n de pacientes con mal pron\u00f3stico a los 3 meses y menor volumen de infarto. La concentraci\u00f3n de tnf-alfa fue significativamente m\u00e1s alta (p&lt;0,0001) y la de il-6 m\u00e1s baja (p&lt;0,0001). En el 92,1% de los pacientes con ait ipsilateral previo se observ\u00f3 la presencia de fbt y sole en el 1,2% de los pacientes sin ait (p&lt;0,0001). Los diferentes modelos de regresi\u00f3n log\u00edstica demostraron que la concentraci\u00f3n de tnf-alfa (p=0,001), pero sobre todo el fbt (p=0,0003) y la presencia de ait ipsilateral en las 72 horas previas a un ictus isqu\u00e9micos (p=0,0001) se asocian con un mejor pron\u00f3st<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>B\u00fasqueda de nuevas dianas terap\u00e9uticas en el ictus isqu\u00e9mico: factor de necrosis tumoral y su papel en la tolerancia isqu\u00e9mica cerebral humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 B\u00fasqueda de nuevas dianas terap\u00e9uticas en el ictus isqu\u00e9mico: factor de necrosis tumoral y su papel en la tolerancia isqu\u00e9mica cerebral humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Blanco Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Castillo S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Noya  Garc\u00eda <\/li>\n<li>Antonio D\u00e1valos errando (vocal)<\/li>\n<li>ignacio Lizasoain hernandez (vocal)<\/li>\n<li>Jos\u00e9 Luis Labandeira garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Blanco Gonzalez Antecedentes y objetivos trabajos previos han demostrado la presencia de tolerancia isqu\u00e9mica en pacientes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,1880,977],"tags":[37943,40281,21386,3006,2879,72179],"class_list":["post-24597","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-neurologia","category-santiago-de-compostela","tag-antonio-davalos-errando","tag-ignacio-lizasoain-hernandez","tag-jose-castillo-sanchez","tag-jose-luis-labandeira-garcia","tag-manuel-noya-garcia","tag-miguel-blanco-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24597"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24597\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}