{"id":24609,"date":"2003-11-07T00:00:00","date_gmt":"2003-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-fenota%c2%adpico-y-funcional-de-los-osteoblastos-humanos-en-cultivo\/"},"modified":"2003-11-07T00:00:00","modified_gmt":"2003-11-07T00:00:00","slug":"analisis-fenota%c2%adpico-y-funcional-de-los-osteoblastos-humanos-en-cultivo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-fenota%c2%adpico-y-funcional-de-los-osteoblastos-humanos-en-cultivo\/","title":{"rendered":"An\u00e1lisis fenot\u00edpico y funcional de los osteoblastos humanos en cultivo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena P\u00e9rez Fern\u00e1ndez <\/strong><\/h2>\n<p>Los osteoblastos humanos son las c\u00e9lulas encargadas de sintetizar la matriz col\u00e1gena que posteriormente es mineralizada para formar el tejido \u00f3seo. Cl\u00e1sicamente se les ha atribuido exclusivamente esta funci\u00f3n de s\u00edntesis. sin embargo, antecedentes bibliogr\u00e1ficos recientes nos llevan a pensar que los osteoblastos pueden desempe\u00f1ar una funci\u00f3n adicional en el tejido \u00f3seo y que pueden ser los factores de crecimiento y citoquinas presentes los que regulan su papel. Con objeto de estudiar esta nueva funci\u00f3n en este trabajo se ha estudiado la expresi\u00f3n en los osteoblastos de distintas citoquinas propias de las c\u00e9lulas estudiadas. Por otro lado, se ha determinado la modulaci\u00f3n de la expresi\u00f3n de estas citoquinas por diversos factores de crecimiento como fgf, tfg-beta1, pdgf, il-1 e ifngama. Tambi\u00e9n se determin\u00f3 la capacidad fagoc\u00edtica de los osteoblastos frente a part\u00edculas de diversa naturaleza.  los resultados obtenidos apuntan a que los osteoblastos inmaduros poseen funciones t\u00edpicamente inmunol\u00f3gicas, como capacidad fagoc\u00edtica, capacidad de estimular alog\u00e9nicamente a los linfocitos t y de sintetizar citoquinas.  todo esto hace pensar que ante una situaci\u00f3n no fisiol\u00f3gica, como un traumatismo o la inserci\u00f3n de un material alopl\u00e1stico en el tejido \u00f3seo que conlleve una respuesta inflamatoria los osteoblastos pueden comportarse como c\u00e9lulas inmunocompetentes, dando lugar a una respuesta inmunol\u00f3gica como la que se lleva a cabo por las c\u00e9lulas presentadoras de ant\u00edgeno.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis fenot\u00edpico y funcional de los osteoblastos humanos en cultivo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis fenot\u00edpico y funcional de los osteoblastos humanos en cultivo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena P\u00e9rez Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Concepcion Ruiz Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Ramos cormenzana <\/li>\n<li>joaqu\u00edn Moreno casco (vocal)<\/li>\n<li>rosario Rubio altamirano (vocal)<\/li>\n<li>consolaci\u00f3n Melguizo alonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena P\u00e9rez Fern\u00e1ndez Los osteoblastos humanos son las c\u00e9lulas encargadas de sintetizar la matriz col\u00e1gena que posteriormente [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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