{"id":24642,"date":"2003-11-07T00:00:00","date_gmt":"2003-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-genica-y-biologa%c2%ada-celular-de-la-frataxina-en-caenorhabditis-elegans\/"},"modified":"2003-11-07T00:00:00","modified_gmt":"2003-11-07T00:00:00","slug":"expresion-genica-y-biologa%c2%ada-celular-de-la-frataxina-en-caenorhabditis-elegans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-genica-y-biologa%c2%ada-celular-de-la-frataxina-en-caenorhabditis-elegans\/","title":{"rendered":"Expresi\u00f3n g\u00e9nica y biolog\u00eda celular de la frataxina en caenorhabditis elegans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Pascual V\u00e1zquez Manrique <\/strong><\/h2>\n<p>En el presente trabajo se ha caracterizado la biolog\u00eda celular del gen frh-1 de caenorhabditis elegans, ort\u00f3logo al gen frda humano, que codifica para la frataxina del nematodo. El objetivo perseguido en el establecimiento de un modelo animal para en el establecimiento de un modelo para la investigaci\u00f3n de la ataxia de friedrich.  primero se caracteriz\u00f3 el gen y su mensajero. Posteriormente se estudi\u00f3 el entorno gen\u00f3mico del gen que resulto estar enmarcado en un oper\u00f3n t\u00edpico de c.Elegans, junto a otros siete genes m\u00e1s.  se ha analizado la expresi\u00f3n del gen frh-1 por tejidos, para tratar de establecer los paralelismos entre el gen humano y el gen de c.Elegans. se ha corroborado que la frataxina del gusano se expresa en tejido que podr\u00edan considerarse an\u00e1logos a los humanos, tales como faringe (coraz\u00f3n), intestino (intestino humano y\/o h\u00edgado), m\u00fasculo de la pared (m\u00fasculo esquel\u00e9tico), etc. Adem\u00e1s de esto se ha confirmado que esta prote\u00edna se expresa siguiendo un patr\u00f3n de expresi\u00f3n subcelular que es consistente con una expresi\u00f3n mitocondrial.  se procedi\u00f3, asi mismo, a la mutag\u00e9nesis del gen, mediante rna interferencia (rnai), con el objetivo de obtener informaci\u00f3n sobre la posible funci\u00f3n del a frataxina. Se obtuvo un fenotipo caracter\u00edstico, que siempre se repiti\u00f3 en diferentes e independientes experimentos, lo que da una idea de que es consistente y repetitivo. Este fenotipo consiste en que los gusanos son m\u00e1s peque\u00f1os y delgados que los gusanos controles (fenotipo estarved). adem\u00e1s tienen problemas con la puesta de huevos (fenotipo egl). Estos fenotipos podr\u00edan estar relacionados con la incapacidad de coordinar el bombeo fra\u00edngeo, cuya frecuencia se haya disminuida y a su vez resulta arr\u00edtmico. Este bombeo es imprescindible para la ingesta de alimento y al estar interferida se podr\u00eda estar produciendo el resto de s\u00edntomas.  por \u00faltimo se testaron diversas sustancias antioxidantes sobre los gusa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n g\u00e9nica y biolog\u00eda celular de la frataxina en caenorhabditis elegans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n g\u00e9nica y biolog\u00eda celular de la frataxina en caenorhabditis elegans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Pascual V\u00e1zquez Manrique <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Palau Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rodr\u00edguez aguilera Juan  Carlos <\/li>\n<li>eugenia Monros marin (vocal)<\/li>\n<li>Mar\u00eda  eugenia Armengod gonzalez (vocal)<\/li>\n<li> Mu\u00f1oz ruiz Manuel Jes\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Pascual V\u00e1zquez Manrique En el presente trabajo se ha caracterizado la biolog\u00eda celular del gen frh-1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[72274,54197,72275,72276,72273,20966],"class_list":["post-24642","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-eugenia-monros-marin","tag-francesc-palau-Martinez","tag-maria-eugenia-armengod-gonzalez","tag-munoz-ruiz-manuel-jesus","tag-rafael-pascual-vazquez-manrique","tag-rodriguez-aguilera-juan-carlos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24642"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24642\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24642"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24642"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}