{"id":24652,"date":"2003-11-07T00:00:00","date_gmt":"2003-11-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-moleculas-pro-inflamatorias-en-modelos-caninos-de-inflamacion-alergica-in-vivo-e-in-vitro\/"},"modified":"2003-11-07T00:00:00","modified_gmt":"2003-11-07T00:00:00","slug":"expresion-de-moleculas-pro-inflamatorias-en-modelos-caninos-de-inflamacion-alergica-in-vivo-e-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-moleculas-pro-inflamatorias-en-modelos-caninos-de-inflamacion-alergica-in-vivo-e-in-vitro\/","title":{"rendered":"Expresi\u00f3n de mol\u00e9culas pro-inflamatorias en modelos caninos de inflamaci\u00f3n al\u00e9rgica in vivo e in vitro"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Montserrat Torres Blanch <\/strong><\/h2>\n<p>La dermatitis at\u00f3pica (da) es una enfermedad al\u00e9rgica de la piel que se manifiesta en individuos at\u00f3picos que entran en contacto con un alergeno frente el cual son hipertensibles. La da se manifiesta en el hombre y en el perro por la aparici\u00f3n s\u00fabita de picor y de lesiones cut\u00e1neas inmediatas (fase temparano o ear). Adem\u00e1s, en un elevado porcentaje de pacientes, la enfermedad evoluciona hacia una fase tard\u00eda (lar) que se sustenta en un proceso inflamatorio y que es responsable posiblemente de los s\u00edntomas cr\u00f3nicos de la enfermedad. En la da humana y canina la inflamaci\u00f3n se constituye mayoritariamente de c\u00e9lulas dendr\u00edticas y linfocitos t. En ambas especies se ha demostrado que la respuesta inmunitaria es inicialmente del tipo th2 y a medida que la enfermedad se hace cr\u00f3nica cambia al tipo th1. Durante el reclutamiento de las c\u00e9lulas inflamatorias se activan entre otras, las mol\u00e9culas de adhesi\u00f3n.  probablemente en dicha actividad participan los mastocitos (mc) de la dermis. la poblaci\u00f3n mastocitaria est\u00e1 en un lugar privilegiado para coordinar el proceso inflamatorio por su situaci\u00f3n anat\u00f3mica pr\u00f3xima a los vasos sangu\u00edneos y por su contenido en mediadores pro-inflamatorios.  el conocimiento de los mecanismos de instauraci\u00f3n de la inflamaci\u00f3n en la da es fundamental para establecer estrategias terap\u00e9uticas encaminadas a reducirla. Nos propusimos estudiar la expresi\u00f3n de la selectina p, el icam-1 y el tnf-alfa en la da, as\u00ed como la contribuci\u00f3n de los mc a su inducci\u00f3n en modelos caninos in vitro e in vivo.  se seleccionaron perros con da espont\u00e1nea en el hospital cl\u00ednic veterinari de la universitat aut\u00f3noma de barcelona. Mediante inmunohistoqu\u00edmica, en las lesiones cut\u00e1neas de los animales seleccionados se observ\u00f3 una mayor expresi\u00f3n de selectina p que en las zonas no lesionadas. Dicho aumento se correlacionaba con una mayor adherencia de los leucocitos al endotelio vascular. Adem\u00e1s, mediante estud<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de mol\u00e9culas pro-inflamatorias en modelos caninos de inflamaci\u00f3n al\u00e9rgica in vivo e in vitro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de mol\u00e9culas pro-inflamatorias en modelos caninos de inflamaci\u00f3n al\u00e9rgica in vivo e in vitro <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Montserrat Torres Blanch <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando De Mora P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lLuis Ferrer caubet <\/li>\n<li>manel Merlos roca (vocal)<\/li>\n<li>Jorge Peyri rey (vocal)<\/li>\n<li>lLuis Santamaria babi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Montserrat Torres Blanch La dermatitis at\u00f3pica (da) es una enfermedad al\u00e9rgica de la piel que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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