{"id":24718,"date":"2018-03-09T09:15:47","date_gmt":"2018-03-09T09:15:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-moleculas-de-adhesion-y-mecanismos-de-trombofilia-en-policitemia-vera-y-trombocitosis-esencial\/"},"modified":"2018-03-09T09:15:47","modified_gmt":"2018-03-09T09:15:47","slug":"expresion-de-moleculas-de-adhesion-y-mecanismos-de-trombofilia-en-policitemia-vera-y-trombocitosis-esencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-moleculas-de-adhesion-y-mecanismos-de-trombofilia-en-policitemia-vera-y-trombocitosis-esencial\/","title":{"rendered":"Expresi\u00f3n de mol\u00e9culas de adhesion y mecanismos de trombofilia en policitemia vera y trombocitosis esencial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dunia De Miguel Llorente <\/strong><\/h2>\n<p>La policitemia vera y la trombocitosis esencial son sindromes mielopro-liferativos con gran morbi\/mortalidad trombohemorragica; los mecanismos de trombosis siguen sin conocerce, se postula que la hiperviscosidad, la edad, las alteraciones vasculares pueden contribuir.  objetivos  1,- conocer las alteraciones de trombofilia plasm\u00e1ticas y moleculares.  2,- determinar las alteraciones del funcionalismo plaquetario.  3,- valorar el da\u00f1o endotelial (fvwag).  4,- analizar la expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n (cd11b\/11c, cd18, cd 62l) en monocitos y neutr\u00f3filos como expresi\u00f3n de activaci\u00f3n leucocitaria.  material y m\u00e9todos  65 pacientes con pv y te, incluidos durante 4 a\u00f1os. Se recogen datos cl\u00ednicos en un cuestionario sobre trombofilia. Se analiza en plasma: proteina s y c, rpca, atiii, anticuerpos antifosfolipido. Estudio molecular de las mutaciones fvleiden, p202210a y 5mthfr. Se analiza por citometr\u00eda de flujo el cd11b\/11c, cd18, cd62l.  resultados  el d\u00e9ficit de proteina s se detect\u00f3 en el 11%, d\u00e9ficit de prote\u00edna c en 3%, 45% mutaci\u00f3n 5mthfr, 14% fvleiden, 11% p20210a.  29% de complicaciones tromb\u00f3ticas. Se detect\u00f3 aumento de fvwag en los pacientes con trombosis. Se vi\u00f3 disminuci\u00f3n de todas las mol\u00e9culas de adhesi\u00f3n en monocitos y neutr\u00f3filos con aspirina.  conclusiones  en pv y te existe activaci\u00f3n del endotelio vascular en caso de trombosis. el uso de aspirina disminuye la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n, cuyo valor esta aumentado en \u00e9stos pacientes sin tratamiento.  palabras clave  smpc, integrinas, fvwag, trombosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de mol\u00e9culas de adhesion y mecanismos de trombofilia en policitemia vera y trombocitosis esencial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de mol\u00e9culas de adhesion y mecanismos de trombofilia en policitemia vera y trombocitosis esencial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dunia De Miguel Llorente <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Burgaleta Alonso De Ozalla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>Fernando Hern\u00e1ndez navarro (vocal)<\/li>\n<li>julio Garc\u00eda su\u00e1rez (vocal)<\/li>\n<li> Cabrera mar\u00edn Jos\u00e9 Rafael (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dunia De Miguel Llorente La policitemia vera y la trombocitosis esencial son sindromes mielopro-liferativos con gran morbi\/mortalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[36307,51971,897,72453,8245,17571],"class_list":["post-24718","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-cabrera-marin-jose-rafael","tag-carmen-burgaleta-alonso-de-ozalla","tag-domingo-espinos-perez","tag-dunia-de-miguel-llorente","tag-fernando-hernandez-navarro","tag-julio-garcia-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24718"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24718\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}