{"id":24789,"date":"2018-03-09T09:15:54","date_gmt":"2018-03-09T09:15:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-vulnerabilidad-celular-de-la-substantia-nigra\/"},"modified":"2018-03-09T09:15:54","modified_gmt":"2018-03-09T09:15:54","slug":"regulacion-de-la-vulnerabilidad-celular-de-la-substantia-nigra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/regulacion-de-la-vulnerabilidad-celular-de-la-substantia-nigra\/","title":{"rendered":"Regulaci\u00f3n de la vulnerabilidad celular de la substantia nigra"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Dopico Jos\u00e9 Antonio <\/strong><\/h2>\n<p>La substancia negra (sn), es un centro integrado funcional en los ganglios basales que concita gran inter\u00e9s por su implicaci\u00f3n en la enfermedad de parkinson (ep), una enfermedad que induce graves trastornos motores en m\u00e1s del 2% de la poblaci\u00f3n mayor de 60 a\u00f1os. La ep cursa por la degeneraci\u00f3n, por causas desconocidas, de las neuronas dopamin\u00e9rgicas de la sn. En el presente trabajo se pretend\u00eda profundizar en el estudio de los posibles factores que influyen en \u00e9sta degeneraci\u00f3n.  para ello, se desarrollaron t\u00e9cnicas experimentales (microdi\u00e1lisis, determinaci\u00f3n de amino\u00e1cidos neurotransmisores, de zinc i\u00f3nico, y la actividad de los transportadores de glutamato), que fueron utilizadas en modelos animales (rata) de la ep.  con esta t\u00e9cnica se evidenci\u00f3 la existencia de reservorios extracelulares de zinc, glicina y taurina en la sn que cumplen los criterios para la identificaci\u00f3n de neurotransmisores de volumen. Estos tres nuevos transmisores de volumen nigrales, presentaron modificaciones durante la degeneraci\u00f3n experimental de las neuronas dopamin\u00e9rgicas que sugiere su implicaci\u00f3n en la misma, circunstancias especialmente relevante en el caso del zinc, cuya interacci\u00f3n con el calcio y el glutamato podr\u00eda ser importante para mantener la progresi\u00f3n de la degeneraci\u00f3n nigral en esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la vulnerabilidad celular de la substantia nigra<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la vulnerabilidad celular de la substantia nigra <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Dopico Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Rodriguez Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Mar\u00eda Evora Garc\u00eda <\/li>\n<li>concepci\u00f3 Marin agustin (vocal)<\/li>\n<li>Jos\u00e9 a. Obeso inchausti (vocal)<\/li>\n<li> Gonz\u00e1lez Garc\u00eda c\u00e1ndido Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Dopico Jos\u00e9 Antonio La substancia negra (sn), es un centro integrado funcional en los ganglios basales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9915],"tags":[3221,38157,72620,72621,9920,10380],"class_list":["post-24789","post","type-post","status-publish","format-standard","hentry","category-la-laguna","tag-carmen-maria-evora-garcia","tag-concepcio-marin-agustin","tag-garcia-dopico-jose-antonio","tag-gonzalez-garcia-candido-manuel","tag-jose-a-obeso-inchausti","tag-manuel-rodriguez-diaz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24789"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24789\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}