{"id":24840,"date":"2018-03-09T09:15:58","date_gmt":"2018-03-09T09:15:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-efectos-de-la-aplicacion-topica-de-imiquimod-al-5-en-la-apoptosis-del-carcinoma-basocelular\/"},"modified":"2018-03-09T09:15:58","modified_gmt":"2018-03-09T09:15:58","slug":"estudio-de-los-efectos-de-la-aplicacion-topica-de-imiquimod-al-5-en-la-apoptosis-del-carcinoma-basocelular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-efectos-de-la-aplicacion-topica-de-imiquimod-al-5-en-la-apoptosis-del-carcinoma-basocelular\/","title":{"rendered":"Estudio de los efectos de la aplicaci\u00f3n t\u00f3pica de imiquimod al 5% en la apoptosis del carcinoma basocelular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Vidal Sarr\u00f3 <\/strong><\/h2>\n<p>El carcinoma basocelular (cbc) es el tumor maligno m\u00e1s frecuente y en nuestro pa\u00eds su incidencia ha aumentado progresivamente en los \u00faltimos a\u00f1os. El tratamiento del cbc se basa en la cirug\u00eda, pero ante el envejecimiento de la poblaci\u00f3n ha surgido la necesidad de poder tratar los pacientes con terapias menos agresivas. Imiquimod es un potente inductor de citocinas, principalmente el interfer\u00f3n, con propiedad inmunomoduladora sobre el sistema inmune innato y adquirido. La inmunoterapia con imiquimod crema al 5% permite tratar los pacientes de modo ambulatorio y ha demostrado ser un tratamiento eficaz en el cbc. El mecanismo de acci\u00f3n de imiquimod en el cbc no es bien conocido y el presente trabajo ha estudiado los efectos de la aplicaci\u00f3n t\u00f3pica de imiquimod al 5% en la apoptosis del cbc, en la expresi\u00f3n de las prote\u00ednas bcl2, p53 y ki67 del cbc, y en el infiltrado inflamatorio peritumoral del cbc.  en el 2001 se dise\u00f1\u00f3 un ensayo cl\u00ednico abierto con 55 cbc tratados con imiquimod crema al 5%. En todos los cbc se obtuvieron 3 biopsias, una antes del tratamiento, otra durante y otra 6 semanas despu\u00e9s del mismo. A partir de muestras congeladas se estudi\u00f3 el \u00edndice apopt\u00f3tico (tunel) del cbc, y a partir de muestras parafinadas se estudi\u00f3 la expresi\u00f3n del bcl2, p53 y ki67 del cbc. En 25 cbc tambi\u00e9n se estudi\u00f3 el infiltrado inflamatorio peritumoral: c\u00e9lulas totales, cd3+, cd8+, cd56+, grancima b+, cd20+, cd68+ y s-100+. Todos los pacientes fueron seguidos durante 18 meses para evaluar la tasa de recidiva de cbc despu\u00e9s del tratamiento. Entre 2001 y 2002 se dise\u00f1\u00f3 un ensayo cl\u00ednico randomizado con imiquimod crema al 5% y su excipiente en 30 cbc. En todos los cbc se obtuvieron 3 biopsias, una antes del tratamiento y dos durante el mismo. A partir de muestras congeladas se estudi\u00f3 el \u00edndice apopt\u00f3tico (tunel) del cbc, y a partir de muestras parafinadas se estudi\u00f3 la expresi\u00f3n de bcl2, p53 y ki67 del cbc.  en 12 cbc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los efectos de la aplicaci\u00f3n t\u00f3pica de imiquimod al 5% en la apoptosis del carcinoma basocelular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los efectos de la aplicaci\u00f3n t\u00f3pica de imiquimod al 5% en la apoptosis del carcinoma basocelular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Vidal Sarr\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agust\u00edn Alomar Munta\u00f1ola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antoni Castells rodellas <\/li>\n<li>Jorge Peyri rey (vocal)<\/li>\n<li>rosa Mar\u00eda Mart\u00ed laborda (vocal)<\/li>\n<li>abelardo Moreno carazo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Vidal Sarr\u00f3 El carcinoma basocelular (cbc) es el tumor maligno m\u00e1s frecuente y en nuestro pa\u00eds [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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