{"id":24879,"date":"2018-03-09T09:16:02","date_gmt":"2018-03-09T09:16:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/delta2425-esterol-metiltransferasa-de-leishmania-major-funcion-biologica-y-estudios-bioqua%c2%admicos-de-la-enzima-recombinante\/"},"modified":"2018-03-09T09:16:02","modified_gmt":"2018-03-09T09:16:02","slug":"delta2425-esterol-metiltransferasa-de-leishmania-major-funcion-biologica-y-estudios-bioqua%c2%admicos-de-la-enzima-recombinante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/delta2425-esterol-metiltransferasa-de-leishmania-major-funcion-biologica-y-estudios-bioqua%c2%admicos-de-la-enzima-recombinante\/","title":{"rendered":"Delta24,(25)-esterol metiltransferasa de leishmania major: funci\u00f3n biol\u00f3gica y estudios bioqu\u00edmicos de la enzima recombinante"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Jim\u00e9nez Jim\u00e9nez M. Carmen <\/strong><\/h2>\n<p>El protozoo par\u00e1sito leishmania major es el agente causal de una de las enfermedades infecciosas que afectan a mayor n\u00famero de personas a nivel mundial.  actualmente existen alrededor de 350 millones de individuos expuestos a la enfermedad, de los cuales cerca de 12 millones de manifiestan, apareciendo 1.5-2 millones de casos nuevos al a\u00f1o. Hoy en d\u00eda la asociaci\u00f3n de leishmaniasis visceral con el sida se considera una enfermedad emergente.  teniendo en cuenta que no existe ninguna terapia totalmente efectiva frente a la infecci\u00f3n, que los f\u00e1rmacos utilizados son muy t\u00f3xicos y la aparici\u00f3n de resistencias a ellos por parte del par\u00e1sito, hace necesario buscar nuevas estrategias para combatir la enfermedad.  la bios\u00edntesis de esteroles es una de las rutas m\u00e1s complejas en c\u00e9lulas eucariotas, en la que intervienen numerosas enzimas que participan en reacciones altamente espec\u00edficas. Existen numerosas inhibidores espec\u00edficos que bloquean distintas enzimas de la ruta, que han demostrado su actividad antiproliferativa frente a leishmania.  en tripanosom\u00e1tidos, el principal esterol sintetizado es el ergosterol, que difere del colesterol, mayoritario en mam\u00edferos, en la presencia de un grupo metilo en la posici\u00f3n 24 del n\u00facleo esteroide. La reacci\u00f3n de metilaci\u00f3n es catalizada por la enzima a24,(25) -esterol metiltransferasa (smt), que est\u00e1 ausente en mam\u00edferos. La escasa informaci\u00f3n existente en la literatura sobre esta eznima, as\u00ed como su potencial como posible diana farmac\u00f3logica en el tratamiento de enfermedades producidas por leishmania, motivaron el establecimiento de los objetivos de este trabajo.  se ha aislado el gen estructural que codifica la prote\u00edna smt de l.Major. se trata de un gen de copia \u00fanica, que se transcribe dando lugar a un mrna de 4.4 kb y se encuentra localizado en un cromosoma de un tama\u00f1o mayor de 2.2 kb. Presenta una pauta abierta de lectura de 1059 nucle\u00f3tidos que codifica una prote<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Delta24,(25)-esterol metiltransferasa de leishmania major: funci\u00f3n biol\u00f3gica y estudios bioqu\u00edmicos de la enzima recombinante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Delta24,(25)-esterol metiltransferasa de leishmania major: funci\u00f3n biol\u00f3gica y estudios bioqu\u00edmicos de la enzima recombinante <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Jim\u00e9nez Jim\u00e9nez M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Dolores Gonz\u00e1lez Pacanowska<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  dolores Suarez ortega <\/li>\n<li>francisca Mar\u00eda Sanchez jimenez (vocal)<\/li>\n<li>basilio Valladares hern\u00e1ndez (vocal)<\/li>\n<li>Francisco Gamarro conde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jim\u00e9nez Jim\u00e9nez M. Carmen El protozoo par\u00e1sito leishmania major es el agente causal de una de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[35395,22318,41389,3371,72834,3372],"class_list":["post-24879","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-basilio-valladares-hernandez","tag-dolores-gonzalez-pacanowska","tag-francisca-maria-sanchez-jimenez","tag-francisco-gamarro-conde","tag-jimenez-jimenez-m-carmen","tag-maria-dolores-suarez-ortega"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24879"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24879\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}