{"id":2488,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/modificaciones-bioquimicas-en-los-receptores-opioides-mu-y-dihidropiridinicos\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"modificaciones-bioquimicas-en-los-receptores-opioides-mu-y-dihidropiridinicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificaciones-bioquimicas-en-los-receptores-opioides-mu-y-dihidropiridinicos\/","title":{"rendered":"Modificaciones bioquimicas en los receptores opioides mu y dihidropiridinicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alvaro Diaz Martinez <\/strong><\/h2>\n<p>En esta tesis doctoral se analizan, mediante tecnicas de fijacion de radioligandos especificos (estudios de \u00abbinding\u00bb y \u00abautorradiografia\u00bb), las modificaciones bioquimicas en los receptores opioides mu y dihidropiridinicos (canales de calcio tipo l) responsables de los estados de tolerancia e hipersensibilidad al agonista opioide mu sufentanil. El desarrollo de tolerancia a la accion analgesica de los opioides va asociada a un aumento de canales de calcio tipo l y a una disminucion de los receptores opioides mu.  el aumento del flujo de calcio a traves de estos canales podria ser un mecanismo adaptativo y responsable de la perdida del efecto de los opioides tras su accion cronica; el papel de la disminucion de receptores opioides mu esta mucho menos claro. Por otra parte, la administracion cronica y simultanea de sufentanil y nimodipina induce hipersensibilidad a la accion analgesica del opioide sin generar modificaciones en la densidad de receptores opioides mu y asociada a un mayor incremento en el numero de canales de calcio tipo l.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones bioquimicas en los receptores opioides mu y dihidropiridinicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones bioquimicas en los receptores opioides mu y dihidropiridinicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alvaro Diaz Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Pazos Carro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez Beledo <\/li>\n<li>Mar\u00eda  Isabel Martin Fontelles (vocal)<\/li>\n<li>Clemente Muriel Villoria (vocal)<\/li>\n<li>Ane Miren Gabilondo Urkijo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvaro Diaz Martinez En esta tesis doctoral se analizan, mediante tecnicas de fijacion de radioligandos especificos (estudios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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