{"id":24884,"date":"2018-03-09T09:16:03","date_gmt":"2018-03-09T09:16:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-distereoselectiva-de-carbociclos-de-cinco-y-siete-eslabones-a-partir-de-complejos-alquenilmetoxicarbeno-de-fischer-y-enolatos-de-litio-de-metil-cetonas\/"},"modified":"2018-03-09T09:16:03","modified_gmt":"2018-03-09T09:16:03","slug":"sintesis-distereoselectiva-de-carbociclos-de-cinco-y-siete-eslabones-a-partir-de-complejos-alquenilmetoxicarbeno-de-fischer-y-enolatos-de-litio-de-metil-cetonas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oviedo\/sintesis-distereoselectiva-de-carbociclos-de-cinco-y-siete-eslabones-a-partir-de-complejos-alquenilmetoxicarbeno-de-fischer-y-enolatos-de-litio-de-metil-cetonas\/","title":{"rendered":"Sintesis distereoselectiva de carbociclos de cinco y siete eslabones a partir de complejos (alquenil)(metoxi)carbeno de fischer y enolatos de litio de metil cetonas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Alonso Alonso <\/strong><\/h2>\n<p>La presente memoria describe los resultados obtenidos en el estudio de la reactividad de enolatos de litio de metil cetonas frente a complejos metal (alquenil)(metoxi)carbeno de fischer.  en el primer cap\u00edtulo se estudian los complejos metal (alquenil)(metoxi)carbeno de fischer -disustituidos, y se describen la formaci\u00f3n diastereoselectiva de carbociclos de cinco eslabones a trav\u00e9s de una ciclaci\u00f3n formal [3+2] y la importante influencia del disolvente en la diastereoselectividad de la reacci\u00f3n, llegando a obtener de forma separada diastereois\u00f3meros opuestos con excelentes rendimientos y diastereoselectividades. Asimismo, en este cap\u00edtulo se describe la formaci\u00f3n complementaria de carbociclos de cinco eslabones a trav\u00e9s de una ciclaci\u00f3n formal [4+1] a partir de este tipo de complejos metal carbeno y enolatos de litio de alquinil metil cetonas.  en el segundo cap\u00edtulo se estudian los complejos metal (alquenil)(metoxi)carbeno de fischer -sustituidos, y se describe la formaci\u00f3n diastereoselectiva de carbociclos de cinco eslabones a trav\u00e9s de ciclaciones formales complementarias [3+2] y [2+2+1], dependiendo del disolvente empleado o del resto r del enolato de litio utilizado. Tambi\u00e9n se describe la formaci\u00f3n diastereoselectiva de anillos de siete eslabones a trav\u00e9s de ciclaciones formales [3+2+2], con el enolato de litio de acetona, y [4+3], con enolatos de litio de alquenil metil cetonas. Este \u00faltimo modelo de ciclaci\u00f3n se ha empleado en la transformaci\u00f3n diastereoselectiva de un producto natural, el (-)-mirtenal. Finalmente se estudian los complejos metal carbeno -diinsaturados, que dan lugar de forma diastereoselectiva a carbociclos de siete eslabones a trav\u00e9s de una ciclaci\u00f3n formal [5+2].  en el tercer cap\u00edtulo se caracterizan qu\u00edmicamente los intermedios propuestos en los cap\u00edtulos anteriores mediante reacciones de tres componentes entre complejos metal (alquenil)(metoxi)carbeno de fischer, enolatos de litio de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis distereoselectiva de carbociclos de cinco y siete eslabones a partir de complejos (alquenil)(metoxi)carbeno de fischer y enolatos de litio de metil cetonas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis distereoselectiva de carbociclos de cinco y siete eslabones a partir de complejos (alquenil)(metoxi)carbeno de fischer y enolatos de litio de metil cetonas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Alonso Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Joaquin Barluenga Mur<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Peric\u00ed\u00a0s brondo <\/li>\n<li> Sierra rodr\u00edguez Miguel angel (vocal)<\/li>\n<li>Antonio  m. Echavarren pablos (vocal)<\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Alonso Alonso La presente memoria describe los resultados obtenidos en el estudio de la reactividad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8846],"tags":[1384,72848,3282,51293,19695,25474],"class_list":["post-24884","post","type-post","status-publish","format-standard","hentry","category-oviedo","tag-antonio-m-echavarren-pablos","tag-jorge-alonso-alonso","tag-jose-joaquin-barluenga-mur","tag-jose-luis-mascarenas-cid","tag-miguel-angel-perici-s-brondo","tag-sierra-rodriguez-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24884"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24884\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}