{"id":24888,"date":"2018-03-09T09:16:03","date_gmt":"2018-03-09T09:16:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-multicomponentes-por-calibracion-univariada-y-multivariante-analisis-de-farmacos\/"},"modified":"2018-03-09T09:16:03","modified_gmt":"2018-03-09T09:16:03","slug":"determinacion-de-multicomponentes-por-calibracion-univariada-y-multivariante-analisis-de-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/determinacion-de-multicomponentes-por-calibracion-univariada-y-multivariante-analisis-de-farmacos\/","title":{"rendered":"Determinaci\u00f3n de multicomponentes por calibraci\u00f3n univariada y multivariante; an\u00e1lisis de f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Luis Luis M. Luz <\/strong><\/h2>\n<p>La memoria aplica la calibraci\u00f3n univariada y multivariante a la determinaci\u00f3n simult\u00e1nea de varios principios activos en mezclas. Los principios activos estudiados pertenecen a las familias de los antihipertensivos y antiepil\u00e9pticos.  en el cap\u00edtulo primero se presentan las caracter\u00edsticas f\u00edsico-qu\u00edmicas y farmacol\u00f3gicas m\u00e1s importantes de los principios activos objeto de estudio, as\u00ed como, su acci\u00f3n en el organismo. El segundo cap\u00edtulo est\u00e1 dedicado a los fundamentos te\u00f3ricos de los distintos m\u00e9todos de calibraci\u00f3n que se utilizar\u00e1n en los cap\u00edtulos siguientes y que permitir\u00e1n llevar a cabo las multideterminaciones.  en el tercer cap\u00edtulo se aborda la resoluci\u00f3n de las diferentes mezclas binarias estudiadas: dihidralazina-hidroclorotiazida, clortalidona-espironolactona y fenito\u00edna-fenobarbital, aplicando calibraci\u00f3n univaridad: m\u00e9todos del \u00abcruce por cero\u00bb y \u00abespectros cocientes derivados\u00bb y, calibraci\u00f3n multivariante: regresi\u00f3n lineal m\u00faltiple (mlr) y regresi\u00f3n en m\u00ednimos cuadrados parciales (pls).  en el cap\u00edtulo cuarto se hace uso de la calibraci\u00f3n multivariante para la resoluci\u00f3n y cuantificaci\u00f3n de las mezclas ternarias dihidralazina-hidroclorotiazida-reserpina y clortalidona-espironolactona-reserpina, resolvi\u00e9ndose la primera por regresi\u00f3n lineal m\u00faltiple y por m\u00ednimos cuadrados parciales. La mezcla clortalidona-espironolactona-reserpina se resuelve por regresi\u00f3n por m\u00ednimos cuadrados parciales.  la capacidad predictora de los diferentes m\u00e9todos de calibraci\u00f3n desarrollados en los cap\u00edtulos anteriores se eval\u00faa mediante el c\u00e1lculo de los par\u00e1metros estimativos del error cometido en las determinaciones, el error est\u00e1ndar de la predicci\u00f3n (rse), el error relativo medio de la predicci\u00f3n (rmse) y la suma de los cuadrados del error residual de predicci\u00f3n (press).  los m\u00e9todos desarollados se aplican con buenos resultados a la determinaci\u00f3n de los principios activos en mezclas sin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de multicomponentes por calibraci\u00f3n univariada y multivariante; an\u00e1lisis de f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de multicomponentes por calibraci\u00f3n univariada y multivariante; an\u00e1lisis de f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Luis Luis M. Luz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Arias Le\u00f3n Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: venerando Gonz\u00e1lez d\u00edaz <\/li>\n<li>domingo Blanco gomis (vocal)<\/li>\n<li>Jos\u00e9 Juan Santana rodriguez (vocal)<\/li>\n<li>zoraida Zosa ferrera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Luis M. Luz La memoria aplica la calibraci\u00f3n univariada y multivariante a la determinaci\u00f3n simult\u00e1nea de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9915],"tags":[6133,8946,7888,72857,2083,72858],"class_list":["post-24888","post","type-post","status-publish","format-standard","hentry","category-la-laguna","tag-arias-leon-juan-jose","tag-domingo-blanco-gomis","tag-jose-juan-santana-rodriguez","tag-luis-luis-m-luz","tag-venerando-gonzalez-diaz","tag-zoraida-zosa-ferrera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24888"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24888\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}