{"id":24942,"date":"2018-03-09T09:16:07","date_gmt":"2018-03-09T09:16:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-polimorfismo-presente-en-el-exon-1-del-gen-del-receptor-scavenger-clase-b-tipo-i-modula-el-efecto-de-la-grasa-alimentaria-sobre-el-colesterol-ldl\/"},"modified":"2018-03-09T09:16:07","modified_gmt":"2018-03-09T09:16:07","slug":"el-polimorfismo-presente-en-el-exon-1-del-gen-del-receptor-scavenger-clase-b-tipo-i-modula-el-efecto-de-la-grasa-alimentaria-sobre-el-colesterol-ldl","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/el-polimorfismo-presente-en-el-exon-1-del-gen-del-receptor-scavenger-clase-b-tipo-i-modula-el-efecto-de-la-grasa-alimentaria-sobre-el-colesterol-ldl\/","title":{"rendered":"El polimorfismo presente en el ex\u00f3n 1 del gen del receptor scavenger clase b tipo i modula el efecto de la grasa alimentaria sobre el colesterol ldl"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Perez Martinez <\/strong><\/h2>\n<p>Objetivo principal  determinar si las variaciones polim\u00f3rficas en el ex\u00f3n 1 (g-a) del gen del sr-bi influyen en la respuesta lip\u00eddica a cambios en el tipo de alimentaci\u00f3n en personas sanas.  objetivo secundario  estudiar si dicha variaci\u00f3n influye en la respuesta de la lipemia postprandial en un subgrupo de esa misma poblaci\u00f3n.  dise\u00f1o y m\u00e9todos  se estudiaron 97 voluntarios sanos, 65 homocigotos para el alelo 1 (1\/1) y 32 heterocigotos para el alelo 2 (1\/2).  los voluntarios recibieron una dieta rica en grasa saturada (sat) (38% grasa, 20% sat) y seguidamente, de forma aleatorizada y cruzada, una rica en hidratos de carbono (hco) (30% grasa, &lt;10% sar, 55% hco) y otra rica en monoinsaturados (mono) (38% grasa, 22% mono). Cada periodo dur\u00f3 cuatro semanas. Tras 12 horas de ayuno, 47 voluntarios homocigotos para el alelo e3 de la apo e (37 con genotipo 1\/1 del sr-bi y 10\/12) consumieron una comida rica en grasa, realiz\u00e1ndose extracciones sangu\u00edneas previamente a la ingesta y posteriormente en las horas 1,2,3,4,5,6, 8.5 y 11.  resultados  los portadores del alelo minoritario 2 (1\/2) presentaron un mayor descenso de las concentraciones de colesterol-ldl (-23%), al sustituir la dieta por la dieta hco, que los portadores del alelo mayoritario 1 (1\/1) (-16%).  este efecto tambi\u00e9n se objetiv\u00f3 tras el consumo de la dieta de tipo mono, ya que mientras en los portadores del alelo 2 (1\/2) se observ\u00f3 un descenso del 20%, en los 1\/1 s\u00f3lo fue del 14%.  la respuesta postprandial de los triglic\u00e9ridos y los retiniles palmitato, vehiculizados en los remanentes de quilomicrones, fueron menores en los portadores del genotipo 1\/2 que en los 1\/1.  conclusiones  las personas portadoreas del alelo minoritario 2 (1\/2) presentan una mayor respuesta lip\u00eddica a la reducci\u00f3n de la grasa saturada de la dieta, al sufrir un mayor descenso del colesterol-ldl al sustituir la dieta rica en grasa sat por la dieta hco y mono, que los portad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El polimorfismo presente en el ex\u00f3n 1 del gen del receptor scavenger clase b tipo i modula el efecto de la grasa alimentaria sobre el colesterol ldl<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El polimorfismo presente en el ex\u00f3n 1 del gen del receptor scavenger clase b tipo i modula el efecto de la grasa alimentaria sobre el colesterol ldl <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Perez Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Lopez Miranda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>Jos\u00e9 Manuel Villalba (vocal)<\/li>\n<li>Mar\u00eda Ordov\u00e1s jos\u00e9 (vocal)<\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Perez Martinez Objetivo principal determinar si las variaciones polim\u00f3rficas en el ex\u00f3n 1 (g-a) del gen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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