{"id":24964,"date":"2018-03-09T09:16:09","date_gmt":"2018-03-09T09:16:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicaciones-de-la-rmn-al-estudio-molecular-de-enfermedades-del-sistema-nervioso-central\/"},"modified":"2018-03-09T09:16:09","modified_gmt":"2018-03-09T09:16:09","slug":"aplicaciones-de-la-rmn-al-estudio-molecular-de-enfermedades-del-sistema-nervioso-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aplicaciones-de-la-rmn-al-estudio-molecular-de-enfermedades-del-sistema-nervioso-central\/","title":{"rendered":"Aplicaciones de la rmn al estudio molecular de enfermedades del sistema nervioso central"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Carmen Mart\u00ednez Bisbal <\/strong><\/h2>\n<p>Este trabajo de investigaci\u00f3n se centr\u00f3 en el estudio del sistema nervioso central (snc) y los efectos en \u00e9l de diversas patolog\u00edas, empleando fundamentalmente la rmn. Se implementaron diversas metodolog\u00edas de espectroscop\u00eda de rmn, en equilibrio entre investigaci\u00f3n b\u00e1sica y aplicaci\u00f3n cl\u00ednica.  la primera patolog\u00eda es la esclerosis m\u00faltiple (em), caracterizada por la existencia de desmielinizaci\u00f3n en lesiones (placas) y da\u00f1o difuso en la sustancia blanca aparentemente normal. Resulta complejo metodol\u00f3gicamente hacer un estudio de todo el da\u00f1o axonal en el snc. Para aumentar la sensibilidad se propuso el troncoenc\u00e9falo y los ped\u00fanculos cerebelosos que concentran gran cantidad de axones, intentando detectar el da\u00f1o axonal precoz y su relaci\u00f3n con la discapacidad funcional y atencional mediante espectroscop\u00eda de resonancia magn\u00e9tica de imagen (ermi). El estudio de troncoenc\u00e9falo y ped\u00fanculos puso de manifiesto por primera vez el aumento de da\u00f1o axonal (degeneraci\u00f3n walleriana) con el tiempo de la evoluci\u00f3n en em en esta regi\u00f3n y que el mayor da\u00f1o axonal ocurre en pacientes activos frente a em (j. neurol. 2003; 250: 22-28).  en el estudio de alteraciones atencionales se combin\u00f3 ermi en troncoenc\u00e9falo (atravesado por el sistema reticular activador, en el locus coeruleus) con la escucha dic\u00f3tica con instrucciones atencionales. Se encontr\u00f3 por primera vez mayor da\u00f1o axonal en ermi en los pacientes con la atenci\u00f3n deteriorada (brain, en prensa 2003). Por otra parte, se estudi\u00f3 el da\u00f1o focalizado con volumen \u00fanico (voi) y tiempo de eco (te) corto para proponer una cronolog\u00e1i bioqu\u00edmica de la desmielinizaci\u00f3n. Las resonancias a 0,9 y 1,3 ppm relacionadas con fragmentos de polip\u00e9ptidos y \u00e1cidos grasos, y el mio-inositol (mi) revelan estado activo en las placas de em (rev. neurol. 2002; 34: 807-812).  los gliomas presentan gran variabilidad cl\u00ednica, morfol\u00f3gica y evolutiva, con dif\u00edcil diagn\u00f3stico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aplicaciones de la rmn al estudio molecular de enfermedades del sistema nervioso central<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aplicaciones de la rmn al estudio molecular de enfermedades del sistema nervioso central <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Carmen Mart\u00ednez Bisbal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bernardo Celda Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Moratal mascarell Jos\u00e9 Mar\u00eda <\/li>\n<li>sebasti\u00e1n Cerd\u00e1n Garc\u00eda-esteller (vocal)<\/li>\n<li>carles Ar\u00fas caralt\u00f3 (vocal)<\/li>\n<li>paloma Ballesteros Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Carmen Mart\u00ednez Bisbal Este trabajo de investigaci\u00f3n se centr\u00f3 en el estudio del sistema nervioso central [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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