{"id":24966,"date":"2018-03-09T09:16:09","date_gmt":"2018-03-09T09:16:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-de-antibioticos-en-pacientes-con-insuficiencia-renal-cronica-en-dialisis\/"},"modified":"2018-03-09T09:16:09","modified_gmt":"2018-03-09T09:16:09","slug":"monitorizacion-de-antibioticos-en-pacientes-con-insuficiencia-renal-cronica-en-dialisis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-de-antibioticos-en-pacientes-con-insuficiencia-renal-cronica-en-dialisis\/","title":{"rendered":"Monitorizaci\u00f3n de antibi\u00f3ticos en pacientes con insuficiencia renal cr\u00f3nica en di\u00e1lisis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Faus Soler M. Teresa <\/strong><\/h2>\n<p>Los pacientes con insuficiencia renal cr\u00f3nica en hemodi\u00e1lisis presentan una gran susceptibilidad a las infecciones por bacterias gram positivas, siendo tratadas de forma sistem\u00e1tica con vancomicina.  la presente memoria describe el comportamiento farmacocin\u00e9tico de vancomicina en una poblaci\u00f3n de pacientes an\u00e9fricos en hemodi\u00e1lisis. La poblaci\u00f3n total (n=23), se subdivide en dos poblaciones, poblaci\u00f3n a (n=11) y poblaci\u00f3n b (n=12). Con la poblaci\u00f3n a se estiman los par\u00e1metros farmacocin\u00e9ticos del antibi\u00f3tico mediante regresi\u00f3n  no lineal por m\u00e1xima verosimilitud en el programa adapt ii. El modelo estructural seleccionado corresponde al modelo bicompartimental, con dos constantes de eliminaci\u00f3n, una correspondiente al periodo interdial\u00edtico, constante de eliminaci\u00f3n end\u00f3gena (kel) y la segunda, al periodo intradial\u00edtico, constante de eliminaci\u00f3n por el dializador (kdial). La varianza residual se explica a trav\u00e9s de un modelo aditivo-proporcional. mediante regresi\u00f3n lineal m\u00faltiple se analiza la influencia de variables antropom\u00e9tricos, cl\u00ednicas y propias de la di\u00e1lisis sobre los par\u00e1metros farmacocin\u00e9ticos del modelo seleccionado. Con la poblaci\u00f3n b, se eval\u00faa la capacidad predictiva del modelo seleccionado en la poblaci\u00f3n a. Para ello, se implementan dos m\u00e9todos de validaci\u00f3n a priori. El primero (pfm) predice las concentraciones plasm\u00e1ticas en la poblaci\u00f3n b a partir de los par\u00e1metros farmacocin\u00e9ticos medios del modelo seleccionado en la poblaci\u00f3n b; el segundo (rlm), realiza las predicciones utilizando los par\u00e1metros farmacocin\u00e9ticos individuales estimados en la poblaci\u00f3n b a partir de las ecuaciones obtenidas anteriormente por regresi\u00f3n lineal m\u00faltiple. Las principales conclusiones extra\u00eddas de la presente memoria son:  1,- vancomicina presenta baja capacidad dializante.  2,- las membranas con mayor capacidad extractiva de vancomicina son polisulfona, seguido de acetato de celulosa, hemo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3n de antibi\u00f3ticos en pacientes con insuficiencia renal cr\u00f3nica en di\u00e1lisis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3n de antibi\u00f3ticos en pacientes con insuficiencia renal cr\u00f3nica en di\u00e1lisis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Faus Soler M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente German Casabo Alos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li> Otero espinar Francisco j. (vocal)<\/li>\n<li>Antonio Rabasco alvarez (vocal)<\/li>\n<li>belen Valenzuela jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Faus Soler M. Teresa Los pacientes con insuficiencia renal cr\u00f3nica en hemodi\u00e1lisis presentan una gran susceptibilidad a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[11840,54411,73033,3310,45348,12342],"class_list":["post-24966","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-rabasco-alvarez","tag-belen-valenzuela-jimenez","tag-faus-soler-m-teresa","tag-marina-herraez-dominguez","tag-otero-espinar-francisco-j","tag-vicente-german-casabo-alos"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24966"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24966\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}