{"id":24973,"date":"2018-03-09T09:16:10","date_gmt":"2018-03-09T09:16:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-estructura-del-transportador-adp-atp-por-espectroscopia-de-infrarrojo-utilizando-metodos-matematicos-de-estrechamiento-y-ajuste-de-bandas\/"},"modified":"2018-03-09T09:16:10","modified_gmt":"2018-03-09T09:16:10","slug":"analisis-de-la-estructura-del-transportador-adp-atp-por-espectroscopia-de-infrarrojo-utilizando-metodos-matematicos-de-estrechamiento-y-ajuste-de-bandas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-estructura-del-transportador-adp-atp-por-espectroscopia-de-infrarrojo-utilizando-metodos-matematicos-de-estrechamiento-y-ajuste-de-bandas\/","title":{"rendered":"An\u00e1lisis de la estructura del transportador adp\/atp por espectroscopia de infrarrojo utilizando m\u00e9todos matem\u00e1ticos de estrechamiento y ajuste de bandas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victor Armando Lorenz Fonfr\u00eda <\/strong><\/h2>\n<p>El transportador adp\/atp (anc2) es una prote\u00edna de membrana localizada en la membrana interna mitocondrial, y cuya funic\u00f3n fisiol\u00f3gica es el intercambio del atp mitocondrial por adp citos\u00f3lico. Se estudi\u00f3 el transportador adp\/atp de la levadura s.Cerevisiae (anc2) inhibiendo con carboxiatractil\u00f3sido (anc2*c-atr), tanto solubilizado en el detergente docecilmalt\u00f3sido como reconstituido en liposomas de fosfatidil colina\/\u00e1cido fosfat\u00eddico.  mediante el an\u00e1lisis de espectros de infrarrojo de prote\u00ednas, obtenidos sin radiaci\u00f3n polarizada y con radiaci\u00f3n polarizada, se puede obtener informaci\u00f3n sobre su estructura, orientaci\u00f3n. Los espectros obtenidos en presencia de d2o permiten determinar la accesibilidad al disolvente. Estos an\u00e1lisis requieren , entre otros, la aplicaci\u00f3n de m\u00e9todos de estrechamiento y de ajuste de bandas, especialmente necesarios para la obtenci\u00f3n de informaci\u00f3n estructural. Se revisaron y ampliaron tres m\u00e9todos de estrechamiento de bandas basados en la desconvoluci\u00f3n: la desconvoluci\u00f3n de fourier, la desconvoluci\u00f3n regularizada (lineal y por m\u00e1xima entrop\u00eda) y la desconvoluci\u00f3n de fourier combinada con predicci\u00f3n lineal. Asimismo se caracteriz\u00f3 el ejuste de bandas desconvuladas por fourier.  el estudio del anc2*c-atr en su forma reconstituida revel\u00f3 un 40% de h\u00e9lices, 15% de l\u00e1minas beta, 30% de giros y 15% de estructuras irregulares. El 40% de h\u00e9lices es coherente en seis h\u00e9lices transmembrana.  la orientaci\u00f3n de \u00e9stas h\u00e9lices respecto a la normal de la membrana se determin\u00f3 en 34-40\u00c2\u00bac. El nivel de intercambio hidr\u00f3geno\/deuterio obtenido fue comparable con el publicado para otros transportadores de mol\u00e9culas hidrof\u00f3bicas, y bastante superior al de los canales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la estructura del transportador adp\/atp por espectroscopia de infrarrojo utilizando m\u00e9todos matem\u00e1ticos de estrechamiento y ajuste de bandas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la estructura del transportador adp\/atp por espectroscopia de infrarrojo utilizando m\u00e9todos matem\u00e1ticos de estrechamiento y ajuste de bandas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victor Armando Lorenz Fonfr\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esteve Padr\u00f3s Morell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ramon Dab\u00e1n joan <\/li>\n<li>ocatvi Vi\u00f1as (vocal)<\/li>\n<li> Rodr\u00edguez arrondo Jos\u00e9 Luis (vocal)<\/li>\n<li>rom\u00ed\u00a0 Tauler ferr\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victor Armando Lorenz Fonfr\u00eda El transportador adp\/atp (anc2) es una prote\u00edna de membrana localizada en la membrana [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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