{"id":24989,"date":"2018-03-09T09:16:11","date_gmt":"2018-03-09T09:16:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patogenia-de-las-lesiones-del-sistema-nervioso-central-en-la-peste-porcina-clasica\/"},"modified":"2018-03-09T09:16:11","modified_gmt":"2018-03-09T09:16:11","slug":"patogenia-de-las-lesiones-del-sistema-nervioso-central-en-la-peste-porcina-clasica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/patogenia-de-las-lesiones-del-sistema-nervioso-central-en-la-peste-porcina-clasica\/","title":{"rendered":"Patogenia de las lesiones del sistema nervioso central en la peste porcina cl\u00e1sica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda De Leaniz Cavalle Ines <\/strong><\/h2>\n<p>Uno de los interrogantes que sigue plante\u00e1ndose es la patogenia de la ppc es el de los mecanismos que dan lugar a la reacci\u00f3n encefal\u00edtica y los cambios que experimentan las c\u00e9lulas del infiltrado.  para intentar desvelar estas interrogantes se llev\u00f3 a cabo este estudio. 28 cerdos large white x landrace se inocularon, v\u00eda intramuscular con la cepa alfort del virus de la ppc, catalogada como virulenta. Muestras de cerebro, cerebelo y m\u00e9dula oblongada fueron sometidas a un estudio estructural, de tunel, inmunohistoqu\u00edmico (ant\u00edgeno v\u00edrico, c\u00e9lulas inmunocompetentes y citoquinas), ultraestructural y de astrocitos.  el estudio estructural revela las primeras alteraciones en el 3 dpi, aunque las lesiones encontradas en este d\u00eda son de escasa importancia, siendo en el 5 dpi cuando las alteraciones aumentan considerablemente, sobre todo en lo que se refiere a la presencia de manguitos perivasculares.  otras lesiones encontradas son satelitosis, hiperemia e infiltrado men\u00edngeo, aunque \u00e9ste solo es importante en el cerebelo. En cuanto a la presencia del ant\u00edgeno v\u00edrico, es el 4 dpi cuando se manifiestan los primero signos de infecci\u00f3n en el infiltrado celular. En d\u00edas sucesivos se detecta presencia de ant\u00edgeno v\u00edrico en c\u00e9lulas circulantes, c\u00e9lulas de la microgl\u00eda y en el espacio man\u00edngeo. A partir del 9 dpi se observa tinci\u00f3n en los manguitos perivasculares y en c\u00e9lulas endoteliales.  el infiltrado celular fue identificado como linfocitos t, tanto cd4+ como cd8+ y en menor medida linfocitos b, siendo la presencia de macr\u00f3fagos muy escasa durante toda la experiencia. Coincidiendo con la presencia de linfocitos t, se produce un aumento en la s\u00edntesis y producci\u00f3n de ifng e il2, citoquinas que pueden jugar un papel importante en la patogenia de la enfermedad en el snc, apuntando hacia la existencia de una respuesta inmune tipo 1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patogenia de las lesiones del sistema nervioso central en la peste porcina cl\u00e1sica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patogenia de las lesiones del sistema nervioso central en la peste porcina cl\u00e1sica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda De Leaniz Cavalle Ines <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Gomez Villamandos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Sierra plana <\/li>\n<li>Rafael Jes\u00fas Astorga m\u00e1rquez (vocal)<\/li>\n<li>Antonio  m. Gazquez ortiz (vocal)<\/li>\n<li>Francisco j. Salguero bodes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda De Leaniz Cavalle Ines Uno de los interrogantes que sigue plante\u00e1ndose es la patogenia de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[494,515,973,20868,495,3030],"tags":[543,40657,73088,40655,19519,73089],"class_list":["post-24989","post","type-post","status-publish","format-standard","hentry","category-ciencias-agrarias","category-ciencias-veterinarias","category-cordoba","category-inmunologia-veterinaria","category-patologia-veterinaria","category-virologia-veterinaria","tag-antonio-m-gazquez-ortiz","tag-francisco-j-salguero-bodes","tag-garcia-de-leaniz-cavalle-ines","tag-jose-carlos-gomez-villamandos","tag-miguel-angel-sierra-plana","tag-rafael-jesus-astorga-marquez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=24989"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/24989\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=24989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=24989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=24989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}