{"id":25017,"date":"2018-03-09T09:16:14","date_gmt":"2018-03-09T09:16:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-de-la-linoleil-coa-desaturasa-de-rata\/"},"modified":"2018-03-09T09:16:14","modified_gmt":"2018-03-09T09:16:14","slug":"regulacion-de-la-expresion-de-la-linoleil-coa-desaturasa-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-de-la-linoleil-coa-desaturasa-de-rata\/","title":{"rendered":"Regulaci\u00f3n de la expresi\u00f3n de la linoleil-coa desaturasa de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> V\u00edctor Puerta Fern\u00e1ndez <\/strong><\/h2>\n<p>Durante los \u00faltimos a\u00f1os se ha dedicado una gran atenci\u00f3n al estudio de los \u00e1cidos grasos poliinsaturados como componentes de membranas biol\u00f3gicas, por ser precursores de diversas mol\u00e9culas que intervienen en procesos de defensa e inflamaci\u00f3n y por participar en la regulaci\u00f3n de la expresi\u00f3n g\u00e9nica.  estos \u00e1cidos grasos juegan papeles importantes en la modulaci\u00f3n de diversas enfermedades tan comunes en la sociedad occidental como la enfermedad coronaria, diversos tipos de c\u00e1ncer, la hipertensi\u00f3n, la diabetes, la artritis reumatoide, des\u00f3rdenes autoinmunes (lupus o nefropat\u00eda) o la enfermedad de crohn.  la *6 y *5 desaturasas son enzimas clave en la regulaci\u00f3n de la s\u00edntesis de \u00e1cidos grasos poilinsaturados de larga cadena y se conoce que se regulan por dos mecanismos distintos, uno a trav\u00e9s del srebp-1c que est\u00e1 asociado a su inducci\u00f3n durante la realimentaci\u00f3n tras un per\u00edodo de ayuno, y otro en el que intervienen el pparalfa asociado al ayuno, esto \u00faltimo se ha puesto de manifiesto en estudios utilizando ratones que carec\u00edan de este receptor nuclear.  la doble regulaci\u00f3n que reciben estas enzimas, por dos factores de transcripci\u00f3n cuyas acciones son opuestas dependiendo del estado nutricional, provocan que los niveles de las enzimas sean siempre similares dependiendo del estado nutricional, provocan que los niveles de las enzimas sean siempre similares independientemente del estado nutricional que se experimente. Por otra parte, la doble regulaci\u00f3n de estas desaturasas contribuye a una producci\u00f3n estable de agpi, que son esenciales para las funciones celulares as\u00ed como para controlar el estado energ\u00e9tico celular, regulando o modificando estos factores de transcripci\u00f3n lip\u00eddicos.  los resultados presentados en esta tesis doctoral indican que:  1,- la linoleil-coa desaturasa de rata debe de estar  regulada tanto a nivel transcripcional, traduccional y postraduccional. Adem\u00e1s las diferencias observad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la expresi\u00f3n de la linoleil-coa desaturasa de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la expresi\u00f3n de la linoleil-coa desaturasa de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 V\u00edctor Puerta Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Suarez Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Medina jimenez <\/li>\n<li>dolores Gonz\u00e1lez pacanowska (vocal)<\/li>\n<li>Alberto Vargas morales (vocal)<\/li>\n<li>julio Boza puerta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de V\u00edctor Puerta Fern\u00e1ndez Durante los \u00faltimos a\u00f1os se ha dedicado una gran atenci\u00f3n al estudio de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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