{"id":25056,"date":"2018-03-09T09:16:17","date_gmt":"2018-03-09T09:16:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-esteroides-citotoxicos-polihidroxilados-de-isis-hippuris-y-serinola%c2%adpidos-de-didemnum-sp-estudios-biogeneticos-de-diterpenos-de-las-gorgonias-eunicea-mammosa-y-briareum-abestinum\/"},"modified":"2018-03-09T09:16:17","modified_gmt":"2018-03-09T09:16:17","slug":"nuevos-esteroides-citotoxicos-polihidroxilados-de-isis-hippuris-y-serinola%c2%adpidos-de-didemnum-sp-estudios-biogeneticos-de-diterpenos-de-las-gorgonias-eunicea-mammosa-y-briareum-abestinum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/a-coruna\/nuevos-esteroides-citotoxicos-polihidroxilados-de-isis-hippuris-y-serinola%c2%adpidos-de-didemnum-sp-estudios-biogeneticos-de-diterpenos-de-las-gorgonias-eunicea-mammosa-y-briareum-abestinum\/","title":{"rendered":"Nuevos esteroides citot\u00f3xicos polihidroxilados de isis hippuris y serinol\u00edpidos de didemnum sp. estudios biogen\u00e9ticos de diterpenos de las gorgonias eunicea mammosa y briareum abestinum"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Saavedra M. Noemi <\/strong><\/h2>\n<p>En la presente memoria se realiz\u00f3 el estudio qu\u00edmico de los siguientes organismos marinos: diacarnus sp.: De esta esponja se aislaron cuatro metabolitos con estructura terp\u00e9nica, en concreto los compuestos 1, 2 y 3 se caracterizan por tener un anillo de cicloperoxo y fueron nuevos productos naturales en el momento de su ailamiento.  didemnum sp. De este tunicado se aislaron dos porfinas conocidas (5-6), as\u00ed como tres nuevos metabolitos denominados didemniserinol\u00edpido b, a y c (7-9) que se caracterizaron por poseer una unidad de serinol, un \u00e1cido alfa,beta-insaturado y un anillo de 6,8-dioxabiciclo[3.2.1]octano muy inusual en compuestos naturales.  isis hippuris: a partir de esta gorgonia se aislaron un total de diecisiete esteroides polioxigenados (10-26), de los cu\u00e1les trece (13-26) resultaron ser nuevos productos naturales. Dado el gran n\u00famero de esteroides aislados se pudieron deducir importantes conclusiones a cerca de la relaci\u00f3n estructura-actividad citot\u00f3xica para estos compuestos.  eunicea mammosa: de esta gorgonia se aislaron cuatro diterpenos con el esqueleto de cembrano, tres de ellos nuevos (27-29) y otro conocido 30. se realiz\u00f3 un estudio biogen\u00e9tico a partir de la preparaci\u00f3n  de un extracto de c\u00e9lulas libres y la inyecci\u00f3n de geranilgeranilpirofosfato marcado radiactivamente.  briareum asbestinum: a partir de esta gorgonia se aislaron seis nuevos metabolitos (31-36) con una estructura diterp\u00e9nica. Ciclobutenbriareina a (32) posee un anillo de ciclobuteno en un sistema de anillos triciclo[8.4.0.0]tetradec-4-eno, el cual no ha sido descrito hasta el momento ni de fuente natural ni de origen sint\u00e9tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos esteroides citot\u00f3xicos polihidroxilados de isis hippuris y serinol\u00edpidos de didemnum sp. estudios biogen\u00e9ticos de diterpenos de las gorgonias eunicea mammosa y briareum abestinum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos esteroides citot\u00f3xicos polihidroxilados de isis hippuris y serinol\u00edpidos de didemnum sp. estudios biogen\u00e9ticos de diterpenos de las gorgonias eunicea mammosa y briareum abestinum <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Saavedra M. Noemi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Jim\u00e9nez Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Plumet ortega <\/li>\n<li>ignacio Manzanares secades (vocal)<\/li>\n<li>alejandro Fernandez barrero (vocal)<\/li>\n<li>Carlos Peinador veira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Saavedra M. Noemi En la presente memoria se realiz\u00f3 el estudio qu\u00edmico de los siguientes organismos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576],"tags":[1887,21664,73244,73242,73243,1652],"class_list":["post-25056","post","type-post","status-publish","format-standard","hentry","category-a-coruna","tag-alejandro-fernandez-barrero","tag-carlos-jimenez-gonzalez","tag-carlos-peinador-veira","tag-gonzalez-saavedra-m-noemi","tag-ignacio-manzanares-secades","tag-joaquin-plumet-ortega"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25056"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25056\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}