{"id":25079,"date":"2018-03-09T09:16:19","date_gmt":"2018-03-09T09:16:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-genes-rsf-implicados-en-el-control-del-ciclo-celular-en-levadura\/"},"modified":"2018-03-09T09:16:19","modified_gmt":"2018-03-09T09:16:19","slug":"caracterizacion-de-genes-rsf-implicados-en-el-control-del-ciclo-celular-en-levadura","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-genes-rsf-implicados-en-el-control-del-ciclo-celular-en-levadura\/","title":{"rendered":"Caracterizaci\u00f3n de genes rsf implicados en el control del ciclo celular en levadura"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ethelvina Queralt Bad\u00eda <\/strong><\/h2>\n<p>En s.Cervisiae, al igual que en c\u00e9lulas de mam\u00edfero, el principal control durante el ciclo celular est\u00e1 situado al final de la fase g1, en un punto llamado start (cross 1995). En start se coordina el crecimiento con la divisi\u00f3n celular; la c\u00e9lula s\u00f3lo entrar\u00e1 en un nuevo ciclo celular si ha alcanzado un tama\u00f1o cr\u00edtico y las condiciones medioambientales son apropiadas. un proceso clave en start es la activaci\u00f3n de un programa de transcripci\u00f3n espec\u00edfico de la fase g1 tard\u00eda. Dos factores de transcripci\u00f3n similares, sbf y mbf, son los responsables de esta regulaci\u00f3n de la expresi\u00f3n g\u00e9nica.  con el objeto de un mejor conocimiento de los mecanismos moleculares que controlan start y la transici\u00f3n g1\/s en el ciclo celular, se inici\u00f3 una estrategia de rastreo gen\u00e9tico dise\u00f1ada para identificar genes cuya mutaci\u00f3n sea letal en combinaci\u00f3n con una deleci\u00f3n en el gen swi4 (igual et al. 1996).  de dicho rastreo se aislaron 14 mutantes rsf (\u00abrequiring swi four\u00bb).  la caracterizaci\u00f3n preliminar de estos mutantes puso de manifiesto que swip4p interviene en muchas y variadas funciones adem\u00e1s, e independientemente, de la regulaci\u00f3n de las ciclinas clni, 2 (igual et al.1997). Durante el presente trabajo se han caracterizado dos de estos mutantes rsf. En el caso del mutante clb5swi4, se ha demostrado la conexi\u00f3n funcional de la ciclina clb5p, de la ruta pkc y el factor de transcripci\u00f3n sbf en procesos de metabolismo del dna y en el mantenimiento de la integridad celular. por otro lado, se ha descrito que el gen rot1, relacionado con la ruta pkc, participa en la salida de mitosis y en citoquinesis.  en el segundo caso, la caracterizaci\u00f3n del mutante msn5swi4 realizada los \u00faltimos a\u00f1os ha permitido identificar una relaci\u00f3n funcional entre el factor de transcripci\u00f3n de ciclo celular sbf y la carioferina msn5p. Tambi\u00e9n se ha demostrado que msn5p participa en el control de start regulando la transcripci\u00f3n dependiente de sb<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de genes rsf implicados en el control del ciclo celular en levadura<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de genes rsf implicados en el control del ciclo celular en levadura <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ethelvina Queralt Bad\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Igual Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Herrero perpi\u00f1an <\/li>\n<li>Andr\u00e9s avelino Bueno nu\u00f1ez (vocal)<\/li>\n<li>marti Aldea malo (vocal)<\/li>\n<li>francesc Posas garriga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ethelvina Queralt Bad\u00eda En s.Cervisiae, al igual que en c\u00e9lulas de mam\u00edfero, el principal control durante el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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