{"id":25132,"date":"2018-03-09T09:16:24","date_gmt":"2018-03-09T09:16:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neurotensina-y-autoestimulacion-de-la-corteza-prefrontal-aspectos-funcionales-y-farmacologicos\/"},"modified":"2018-03-09T09:16:24","modified_gmt":"2018-03-09T09:16:24","slug":"neurotensina-y-autoestimulacion-de-la-corteza-prefrontal-aspectos-funcionales-y-farmacologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neurotensina-y-autoestimulacion-de-la-corteza-prefrontal-aspectos-funcionales-y-farmacologicos\/","title":{"rendered":"Neurotensina y autoestimulaci\u00f3n de la corteza prefrontal: aspectos funcionales y farmacol\u00f3gicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Remedios Fern\u00e1ndez Vald\u00e9s <\/strong><\/h2>\n<p>Esta tesis estudia la participaci\u00f3n de la neurotensina en el sustrato neuroqu\u00edmico del proceso de autoestimulaci\u00f3n obtenido en la corteza prefrontal de la rata. As\u00ed, mediante la utilizaci\u00f3n de inhibidores de las enzimas que inactivan la neurotensina, como el tiorfano y de la bestatina que inhibe las enzimas que inactivan la neuromedina n, un an\u00e1logo de la neurotensina, se muestra una potenciaci\u00f3n de los efectos de dichos neuropeptidos sobre esta conducta. Por otra parte y mediante la utilizaci\u00f3n del sr-48692, un antagonista de los receptroes neurotensin\u00e9rgicos, se demuestra que los efectos de la neurotensina se deben a la implicaci\u00f3n de estos receptores y no a otros posibles mecanismos como la formaci\u00f3n de complejos extracelulares neurotensina-dopamina.  la metodolog\u00eda utilizada ha consistido en la implantaci\u00f3n estereot\u00e1xica en la corteza prefrontal medial de ratas albinas de electrodos monopolares para la esimulaci\u00f3n el\u00e9ctrica cerebral y de c\u00e1nulas para la administraci\u00f3n intracerebral de la neurotensina, neuromedina n y de los inhibidores tiorfano y bestatina. Tras diversas sesiones de entrenamiento para obtener la conducta de autoestimulaci\u00f3n se procedi\u00f3 a la administraci\u00f3n de los neurop\u00e9ptidos y de las drogas anteriores, estudi\u00e1ndose sus efectos sobre dicha conducta.  el inter\u00e9s de la presente tesis doctoral radica en:  1,- el creciente papel de la corteza prefrontal en la fisiopatolog\u00eda de la esquizofrenia.  2,- la participaci\u00f3n de la neurotensina en la neuroqu\u00edmica de esta enfermedad.  estudios recientes muestran que la corteza prefrontal es una de las \u00e1reas cerebrales especialmente alterada en la esquizofrenia y que determinan la aparici\u00f3n y desarrollo de los signos negativos y d\u00e9ficits cognitivos caracter\u00edsticos de la esquizofrenia.  por otra parte, estudios neurofarmacol\u00f3gicos muestran que la neurotensina tiene propiedades similares a los antipsic\u00f3ticos at\u00edpicos.  en este sentido, la presen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neurotensina y autoestimulaci\u00f3n de la corteza prefrontal: aspectos funcionales y farmacol\u00f3gicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neurotensina y autoestimulaci\u00f3n de la corteza prefrontal: aspectos funcionales y farmacol\u00f3gicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Remedios Fern\u00e1ndez Vald\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/07\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Rodr\u00edguez Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ramirez sanchez <\/li>\n<li> Saez moreno Jos\u00e9 Antonio (vocal)<\/li>\n<li>Francisco Alba arag\u00ed\u00bcez (vocal)<\/li>\n<li>manuela Cobo aceituno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Remedios Fern\u00e1ndez Vald\u00e9s Esta tesis estudia la participaci\u00f3n de la neurotensina en el sustrato neuroqu\u00edmico del proceso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[12966,4277,3669,73429,73428,37560],"class_list":["post-25132","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-francisco-alba-aragiez","tag-jose-manuel-rodriguez-ferrer","tag-manuel-ramirez-sanchez","tag-manuela-cobo-aceituno","tag-remedios-fernandez-valdes","tag-saez-moreno-jose-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25132"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25132\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}