{"id":25159,"date":"2018-03-09T09:16:26","date_gmt":"2018-03-09T09:16:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/intoxicacion-por-paracetamol-biopatologa%c2%ada-del-sistema-de-protea%c2%adnas-de-choque-termico\/"},"modified":"2018-03-09T09:16:26","modified_gmt":"2018-03-09T09:16:26","slug":"intoxicacion-por-paracetamol-biopatologa%c2%ada-del-sistema-de-protea%c2%adnas-de-choque-termico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/intoxicacion-por-paracetamol-biopatologa%c2%ada-del-sistema-de-protea%c2%adnas-de-choque-termico\/","title":{"rendered":"Intoxicaci\u00f3n por paracetamol: biopatolog\u00eda del sistema de prote\u00ednas de choque t\u00e9rmico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Asensio Rubio <\/strong><\/h2>\n<p>El organismo responde a la agresi\u00f3n mediante un procedimiento homeost\u00e1tico de car\u00e1cter inmediato, universal e inespec\u00edfico. La c\u00e9lula activa, como consecuencia del estr\u00e9s, la denominada respuesta al choque t\u00e9rmico (hsr), ello va a suponer un incremento en la s\u00edntesis de distintos miembros de una familia de prote\u00ednas denominada prote\u00ednas de choque t\u00e9rmico (hsps), que participan en las principales rutas metab\u00f3licas activadas por estr\u00e9s. el paracetamol (acetaminofeno, apap) es un analg\u00e9sico, antipir\u00e9tico de uso com\u00fan, que induce necrosis hep\u00e1tica a partir de sus metabolitos (n-acetil-p-benzoquinona imina), cuando, por sobredosificaci\u00f3n, se agotan las v\u00edas metab\u00f3licas comunes.  esta necrosis est\u00e1 directamente relacionada con su uni\u00f3n por enlaces covalentes a prote\u00ednas tisulares. Se ha descrito una fuerte uni\u00f3n del apa al tejido mioc\u00e1rdico y, ocasionalmente, da\u00f1o cardiaco agudo. Los leucocitos polimorfonucleares neutr\u00f3filos (pmns) representan la 1\u00aa l\u00ednea de reconocimiento y defensa ante agresiones externas y son las c\u00e9lulas fundamentales durante la respuesta inflamatoria local y sist\u00e9mica aguda. Se consideran eficaces biosensores.  el estudio se plante\u00f3 dos objetivos:  estudiar la hsr en h\u00edgado, miocardio y pmns de rata, tras intoxicaciones aguda (ia) con paracetamol y estudiar la utilidad de los pmns como posibles biosensores en la ia con paracetamol.  se eligieron como modelo animal: ratas wistar, (250 g) que se distribuyeron en 8 grupos: 3 grupos de a los que se someti\u00f3 a ia.  en los dos primeros se empleo la misma v\u00eda (ip) y la misma dosis (750 mg\/kg) y se determinaron diferentes tiempos de sacrificio, 4 horas en un caso y 24 en el otro. En el tercer grupo la intoxicaci\u00f3n se realiz\u00f3 por v\u00eda oral, la dosis fue 2g\/kg y la eutanasia a las 24 horas. Por cada grupo de problema se incluy\u00f3 un grupo simulado de animales a los que se administr\u00f3 vol\u00famenes similares de suero fisiol\u00f3gico. Por \u00faltimo, se ag<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Intoxicaci\u00f3n por paracetamol: biopatolog\u00eda del sistema de prote\u00ednas de choque t\u00e9rmico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Intoxicaci\u00f3n por paracetamol: biopatolog\u00eda del sistema de prote\u00ednas de choque t\u00e9rmico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Asensio Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/08\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Garcia Barreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Rodr\u00edguez s\u00e1nchez <\/li>\n<li> Fernandez santaren Juan  Antonio (vocal)<\/li>\n<li>Mar\u00eda Cascales angosto (vocal)<\/li>\n<li>Juan  Manuel Bell\u00f3n caneiro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Asensio Rubio El organismo responde a la agresi\u00f3n mediante un procedimiento homeost\u00e1tico de car\u00e1cter inmediato, universal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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