{"id":25160,"date":"2018-03-09T09:16:26","date_gmt":"2018-03-09T09:16:26","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biodiagnostico-de-las-enfermedades-por-priones-humanas\/"},"modified":"2018-03-09T09:16:26","modified_gmt":"2018-03-09T09:16:26","slug":"biodiagnostico-de-las-enfermedades-por-priones-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/biodiagnostico-de-las-enfermedades-por-priones-humanas\/","title":{"rendered":"Biodiagn\u00f3stico de las enfermedades por priones humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Sanchez-valle Diaz <\/strong><\/h2>\n<p>Introducci\u00f3n  las encefalopat\u00edas espongiformes transmisibles (eet) o enfermedades por priones son un grupo de enfermedades neurodegenerativas letales que afectan al ser humano y a otros mam\u00edferos. El agente causal de estas enfermedades es el pri\u00f3n, que es una isoforma an\u00f3mala de una prote\u00edna celular normal codificada en el gen prnp. La organizaci\u00f3n mundial de la salud, en 1998, estableci\u00f3, para el diagn\u00f3stico de las enfermedades pri\u00f3nicas humanas, las categor\u00edas de definitivo, probable y posible. El diagn\u00f3stico se confirma en el estudio neuropatol\u00f3gico, o, en el caso de las formas gen\u00e9ticas, en el an\u00e1lisis gen\u00e9tico si este demuestra la presencia de una mutaci\u00f3n patog\u00e9nica en el gen prnp. El diagn\u00f3stico de ecj in vivo, con categor\u00eda de probable, se realiza cuando a una serie de criterios cl\u00ednicos se a\u00f1ade la presencia de complejos peri\u00f3dicos en el eeg o la prueba de prote\u00edna 14-3-3 positiva en el caso de las formas espor\u00e1dicas. Con el nombre de prote\u00edna 14-3-3 se denomia a una familia de prote\u00ednas especialmente abundante en sistema nervioso central y su detecci\u00f3n a trav\u00e9s de un m\u00e9todo de inmunoblot, se demostr\u00f3 que se asociaba al diagn\u00f3stico de ecj espor\u00e1dica.  objetivos  0bjetivo 1  estudiar la evoluci\u00f3n de la demanda y la validez de la prueba de prote\u00edna 14-3-3 durante el periodo 1997-2000 en espa\u00f1a.  0bjetivo 2  mejorar la sensibilidad y especificidad de la prueba de la prote\u00edna 14-3- para el diagn\u00f3stico de enfermedad de creutzfeld-jakob (ecj) y analizar los patrones at\u00edpicos en el resultado de la prueba.  objetivo 3  analizar el polimorfismo del exon 1 del gen tau en enfermedades por priones y determinar si este modifica la predisposici\u00f3n a padecer enfermedades pri\u00f3nicas o la expresi\u00f3n cl\u00ednica de estas.  objetivo 4  caracterizar cl\u00ednica y gen\u00e9ticamente las enfermedades por priones humanas en catalu\u00f1a en el periodo 1993-2001.  trabajos  que conforman esta tesis doctoral;<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biodiagn\u00f3stico de las enfermedades por priones humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biodiagn\u00f3stico de las enfermedades por priones humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Sanchez-valle Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/08\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Saiz Hinarejos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jose Zarranz imirizaldu <\/li>\n<li> Pedro cuesta Jes\u00fas de (vocal)<\/li>\n<li>Mar\u00eda Gasset vega (vocal)<\/li>\n<li>Rafael Blesa gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Sanchez-valle Diaz Introducci\u00f3n las encefalopat\u00edas espongiformes transmisibles (eet) o enfermedades por priones son un grupo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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