{"id":25222,"date":"2003-08-09T00:00:00","date_gmt":"2003-08-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-molecular-mediante-pcr-del-papel-que-desempenan-la-infeccion-por-citomegalovirus-y-la-expresion-de-glicoprotea%c2%adna-p-en-el-fracaso-del-injerto-renal\/"},"modified":"2003-08-09T00:00:00","modified_gmt":"2003-08-09T00:00:00","slug":"analisis-molecular-mediante-pcr-del-papel-que-desempenan-la-infeccion-por-citomegalovirus-y-la-expresion-de-glicoprotea%c2%adna-p-en-el-fracaso-del-injerto-renal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-molecular-mediante-pcr-del-papel-que-desempenan-la-infeccion-por-citomegalovirus-y-la-expresion-de-glicoprotea%c2%adna-p-en-el-fracaso-del-injerto-renal\/","title":{"rendered":"An\u00e1lisis molecular mediante pcr del papel que desempe\u00f1an la infecci\u00f3n por citomegalovirus y la expresi\u00f3n de glicoprote\u00edna p en el fracaso del injerto renal"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Espigares Fuentes M. Bel\u00e9n <\/strong><\/h2>\n<p>Este trabajo de tesis doctoral ha pretendido abordar tanto objetivos de \u00edndoles tecnol\u00f3gica, referidos al desarrollo de m\u00e9todos moleculares fiables de detecci\u00f3n de la infecci\u00f3n por citomegalovirus (cmv), as\u00ed como comprobar mediante algunos objetivos cl\u00ednico-patol\u00f3gicos la utilidad de dichos procedimientos en el control de los pacientes trasplantados, dado que, a pesar de los avances terap\u00e9uticos en la medicina antiviral en los \u00faltimos tiempos, la infecci\u00f3n activa por cmv sigue siendo un problema de primer orden para dichos pacientes.  con este fin se plantearon como objetivos, el desarrollo y optimizaci\u00f3n, por un lado, de procedimientos de detecci\u00f3n de adn y arn mensajero de cmv en secciones de tejido renal fijado en formalina tamponada e incluido en parafina, mediante pcr y rt-pcr, y por otro, el desarrollo y optimizaci\u00f3n de una metodolog\u00eda de detecci\u00f3n \u00abin situ\u00bb de adn viral, sobre estas mismas muestras, mediante las t\u00e9cnicas de hibridaci\u00f3n y pcr \u00abin situ\u00bb.  adem\u00e1s, y con independencia a lo anteriormente expuesto, se ha incluido un estudio espec\u00edfico del fen\u00f3meno mdr vinculado a la glicoprote\u00edna p, con la finalidad de comprobar si los pacientes que muestran tasas elevadas de expresi\u00f3n del gen mdr1, con alta incidencia de rechazo agudo y cr\u00f3nico del injerto, opuestamente pod\u00edan mostrar una menor tasa de infecci\u00f3n activa por cmv, al tener menores niveles de inmunosupresi\u00f3n.  para llevar a cabo este estudio, se procedi\u00f3 a la optimizaci\u00f3n de la t\u00e9cnica de rt-pcr para la detecci\u00f3n de arnm del gen mdr1 en biopsias renales postrasplante fijadas en formalina tamponada e incluidas en parafina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis molecular mediante pcr del papel que desempe\u00f1an la infecci\u00f3n por citomegalovirus y la expresi\u00f3n de glicoprote\u00edna p en el fracaso del injerto renal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis molecular mediante pcr del papel que desempe\u00f1an la infecci\u00f3n por citomegalovirus y la expresi\u00f3n de glicoprote\u00edna p en el fracaso del injerto renal <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Espigares Fuentes M. Bel\u00e9n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Asunci\u00f3n Olmo Sevilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raimundo Garc\u00eda delmoral garrido <\/li>\n<li>guillermo S\u00e1nchez salgado (vocal)<\/li>\n<li>agust\u00edn Acevedo barber\u00e1 (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Espigares Fuentes M. Bel\u00e9n Este trabajo de tesis doctoral ha pretendido abordar tanto objetivos de \u00edndoles tecnol\u00f3gica, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[73655,22229,73654,3157,21723],"class_list":["post-25222","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-agustin-acevedo-barbera","tag-asuncion-olmo-sevilla","tag-espigares-fuentes-m-belen","tag-guillermo-sanchez-salgado","tag-raimundo-garcia-delmoral-garrido"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25222"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25222\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}