{"id":2523,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/efectos-de-los-farmacos-empleados-en-el-tratamiento-de-la-osteoporosis-sobre-la-produccion-de-citocinas-estimuladoras-de-la-resorcion-osea\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"efectos-de-los-farmacos-empleados-en-el-tratamiento-de-la-osteoporosis-sobre-la-produccion-de-citocinas-estimuladoras-de-la-resorcion-osea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-farmacos-empleados-en-el-tratamiento-de-la-osteoporosis-sobre-la-produccion-de-citocinas-estimuladoras-de-la-resorcion-osea\/","title":{"rendered":"Efectos de los farmacos empleados en el tratamiento de la osteoporosis sobre la produccion de citocinas estimuladoras de la resorcion osea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tomas Vega Santos <\/strong><\/h2>\n<p>Las citocinas oseas probablemente estan implicadas en la patogenia de la osteoporosis. Nos cuestionamos si los farmacos empleados en su tratamiento modulan la produccion de citocinas resorbedoras de hueso. Hemos realizado un estudio in vitro en el que se valora el efecto del estradiol, etidronato, calcitonina y calcitriol sobre la produccion de il-1 tnf e il-6 por parte de las celulas monocitarias sanguineas y celulas osteoblasticas, en situacion basal y en presencia de agentes estimuladores celulares, entre ellos fragmentos oseos. Es posible que el estradiol y el etidronato ejerzan al menos parte de su efecto resortivo a traves de la modulacion de la sintesis de citocinas oseas: el estradiol reduce la sintesis monocitaria de il-1 y tnf, en distintas condiciones; el etidronato inhibe la sintesis monocitaria de las 3 citocinas inducida por las particulas oseas. La calcitonina aumenta la produccion monocitaria de il-1 y tnf. La sintesis osteoblastica de il-6 queda anulada cuando se asocian las particulas oseas y el etidronato o la calcitonina.  el calcitriol reduce la sintesis osteoblastica de il-1 e il-6, resultando variable el efecto sobre el tnf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los farmacos empleados en el tratamiento de la osteoporosis sobre la produccion de citocinas estimuladoras de la resorcion osea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los farmacos empleados en el tratamiento de la osteoporosis sobre la produccion de citocinas estimuladoras de la resorcion osea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tomas Vega Santos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Gonzalez  Macias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Florez Beledo <\/li>\n<li>Aurelio Rapado Ewatzi (vocal)<\/li>\n<li>Vicente Vicente Garcia (vocal)<\/li>\n<li> Amado Se\u00f1aris Jos\u00e9 A. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tomas Vega Santos Las citocinas oseas probablemente estan implicadas en la patogenia de la osteoporosis. Nos cuestionamos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,155,9,135,213,156],"tags":[10714,10713,9872,9586,10712,8242],"class_list":["post-2523","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-clinicas","category-ciencias-medicas","category-ginecologia","category-osteopatologia","category-patologia","tag-amado-senaris-jose-a","tag-aurelio-rapado-ewatzi","tag-jesus-florez-beledo","tag-jesus-gonzalez-macias","tag-tomas-vega-santos","tag-vicente-vicente-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2523"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2523\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}