{"id":25278,"date":"2003-11-09T00:00:00","date_gmt":"2003-11-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-efectos-miotroficos-ejercidos-por-extractos-musculares-obtenidos-en-diferentes-pera%c2%adodos-postdenervacion\/"},"modified":"2003-11-09T00:00:00","modified_gmt":"2003-11-09T00:00:00","slug":"estudio-de-los-efectos-miotroficos-ejercidos-por-extractos-musculares-obtenidos-en-diferentes-pera%c2%adodos-postdenervacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-efectos-miotroficos-ejercidos-por-extractos-musculares-obtenidos-en-diferentes-pera%c2%adodos-postdenervacion\/","title":{"rendered":"Estudio de los efectos miotr\u00f3ficos ejercidos por extractos musculares obtenidos en diferentes per\u00edodos postdenervaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Ayuso Baptista <\/strong><\/h2>\n<p>En el presente trabajo de investigaci\u00f3n se plantea la hip\u00f3tesis de que el efecto miotr\u00f3fico del extracto de m\u00fasculo denervado puede estar condicionado por el tiempo transcurrido desde la denervaci\u00f3n hasta la obtenci\u00f3n del extracto. Se han empleado extractos de m\u00fasculo s\u00f3leo de rata adulta obtenidos tras 1 hora, 2, 4, y 7 d\u00edas tras la secci\u00f3n del nervio ci\u00e1tico, que se administraron v\u00eda i.P., A ratas normales.  finalizados los tratamientos se estudian muestran de los m\u00fasculos s\u00f3leo que se procesan para su an\u00e1lisis con t\u00e9cnicas histol\u00f3gicas, histoqu\u00edmicas e inmunohistoqu\u00edmicas en microscop\u00eda \u00f3ptica as\u00ed como para microscop\u00eda electr\u00f3nica; la valoraci\u00f3n de los efectos mitr\u00f3ficos se realiza con par\u00e1metros cuantitativos y morfom\u00e9tricos.  los resultados confirman la hip\u00f3tesis inical de que el tiempo postdenervaci\u00f3n influye sobre el efecto miotr\u00f3fico, siendo los extractos obtenidos tras 2 y 4 d\u00edas postdenervaci\u00f3n los que provocan una mayor respuesta hipertr\u00f3fica muscular. Adem\u00e1s, la neoformaci\u00f3n de fibras musculares que se observa tiene lugar preferentemente en la regi\u00f3n perimisial, frente al territorio intrafascicular, y que parece estar motivada por la existencia a ese nivel de c\u00e9lulas con potencialidad miog\u00e9nica entre otras razones. Simult\u00e1neamente a los cambios propl\u00e1sicos observados, los extractos musculares provocaron la aparici\u00f3n de fibras musculares intermedias y un cambio en fenotipo histoqu\u00edmico para nadh-tr y pas que apoyan una transformaci\u00f3n de tipos de fibras en la direcci\u00f3n tipo 1 hacia tipo 2.  todos estos resultados ponen de manifiesto que factores ligados a la inervaci\u00f3n est\u00e1n implicados en los procesos no s\u00f3lo de crecimiento muscular sino tambi\u00e9n en la regulaci\u00f3n de la plasticidad de las fibras musculares adultas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los efectos miotr\u00f3ficos ejercidos por extractos musculares obtenidos en diferentes per\u00edodos postdenervaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los efectos miotr\u00f3ficos ejercidos por extractos musculares obtenidos en diferentes per\u00edodos postdenervaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Ayuso Baptista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Pe\u00f1a Amaro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Lancho alonso <\/li>\n<li>pascual vicente Crespo ferrer (vocal)<\/li>\n<li>ignacio P\u00e9rez de vargas ferroni (vocal)<\/li>\n<li>in\u00e9s Mart\u00edn lacave (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Ayuso Baptista En el presente trabajo de investigaci\u00f3n se plantea la hip\u00f3tesis de que el efecto 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