{"id":25281,"date":"2003-11-09T00:00:00","date_gmt":"2003-11-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-polimorfismo-hla-genomico-y-alteraciones-orales-en-pacientes-con-enfermedad-cela%c2%adaca-y-familiares-de-primer-grado\/"},"modified":"2003-11-09T00:00:00","modified_gmt":"2003-11-09T00:00:00","slug":"estudio-del-polimorfismo-hla-genomico-y-alteraciones-orales-en-pacientes-con-enfermedad-cela%c2%adaca-y-familiares-de-primer-grado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-polimorfismo-hla-genomico-y-alteraciones-orales-en-pacientes-con-enfermedad-cela%c2%adaca-y-familiares-de-primer-grado\/","title":{"rendered":"Estudio del polimorfismo hla gen\u00f3mico y alteraciones orales en pacientes con enfermedad cel\u00edaca y familiares de primer grado"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Jacinto Ortega Paez <\/strong><\/h2>\n<p>Introducci\u00f3n  se ha descrito la asociaci\u00f3n de la enfermedad cel\u00edaca con los hla de clase ii (dr y dq) y con las enfermedades dentales.  objetivos  1,- describir las frecuencias de aparici\u00f3n de los distintos hla clase ii dr y dqb1 en una poblaci\u00f3n de cel\u00edacos y de familiares de primer grado, y analizar sus diferencias.  2,- describir las asociaciones de los hla clase ii dr y dqb1 con una serie de variables cl\u00ednicas y anal\u00edticas en los pacientes cel\u00edacos.  3,- describir la frecuencia de aparici\u00f3n de alteraciones del esmalte dental en los cel\u00edacos, familiares de primer grado y en un grupo control poblacional, y el an\u00e1lisis comparativo de los mismos.  4,- analizar si existe relaci\u00f3n entre las alteraciones del esmalte dentral y los hla de clase ii dr y dqb1.  material y m\u00e9todos  se recogen dos grupos formados por cien cel\u00edacos y sus familiares de primer grado (padres, madres y hermanos) en los que se determinaron variables cl\u00ednicas, anal\u00edticas (entre ellas el polimorfismo hla locus drb1 y dqb1 mediante t\u00e9cnica de pcr) y dentales (grados de hipoplasia seg\u00fan clasificaci\u00f3n de aine e \u00edndices de caries) y dos grupos control constituidos por 38 ni\u00f1os que no presentaban s\u00edntomas sugestivos de enfermedad cel\u00edaca y 478 donantes de sangre.  resultados  los hla dr3, dr7 dr3\/7, hla dqb1* 02, dqb1* 0201, y dqb1* 0201\/0202 eran m\u00e1s frecuentes con diferencias estad\u00edsticamente significativas, en el grupo de cel\u00edacos respecto a los controles y los hla dr1, dr13, dr15, dqb1*03, dqb1* 04, dqb1* 05 y dqb1* 06 eran m\u00e1s frecuentes en los controles respecto a los cel\u00edacos.  en los familiares de primer grado presentaban mayores cifras estad\u00edsticamente significativas de hla dr3, y dr3\/7, dqb1* 02, dqb1* 0201, dqb1* 0201\/0202 que los controles.  las cifras de dr15 estaban disminuidas significativamente en cada uno de los familiares respecto a los controles.  los cel\u00edacos respecto a los familiares ten\u00edan mayores cifras d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del polimorfismo hla gen\u00f3mico y alteraciones orales en pacientes con enfermedad cel\u00edaca y familiares de primer grado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del polimorfismo hla gen\u00f3mico y alteraciones orales en pacientes con enfermedad cel\u00edaca y familiares de primer grado <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Jacinto Ortega Paez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pilar Junco Lafuente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Molina font <\/li>\n<li>Manuel Molina arias (vocal)<\/li>\n<li>federico Arguelles martin (vocal)<\/li>\n<li>encarnaci\u00f3n Gonz\u00e1lez rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Jacinto Ortega Paez Introducci\u00f3n se ha descrito la asociaci\u00f3n de la enfermedad cel\u00edaca con los hla [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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