{"id":25285,"date":"2003-11-09T00:00:00","date_gmt":"2003-11-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-producidos-por-la-matriz-de-los-aloinjertos-sobre-las-celulas-oseas-del-receptor\/"},"modified":"2003-11-09T00:00:00","modified_gmt":"2003-11-09T00:00:00","slug":"efectos-producidos-por-la-matriz-de-los-aloinjertos-sobre-las-celulas-oseas-del-receptor","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-producidos-por-la-matriz-de-los-aloinjertos-sobre-las-celulas-oseas-del-receptor\/","title":{"rendered":"Efectos producidos por la matriz de los aloinjertos sobre las c\u00e9lulas oseas del receptor"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodr\u00edguez De Acu\u00f1a Martinez Lucrecia <\/strong><\/h2>\n<p>La incorporaci\u00f3n de un aloinjerto \u00f3seo est\u00e1 acompa\u00f1ada de una cascada de eventos en la que participan factores sist\u00e9micos (pth, 1,25(oh)2 vitamina d3) y locales (il1, il6, tnfalfa, m-csf, bmp, igf, fgf, tgfbeta, pdgf). estos factores, ejercen su actividad a trav\u00e9s de las acciones realizadas por los osteoblastos y osteoclastos del receptor. Recientemente se ha demostrado el papel del sistema opg\/rankl en la regulaci\u00f3n de la resorci\u00f3n osteocl\u00e1stica.  por otro lado, se ha visto que la conocida citoquina resortiva, il6, puede ejercer un efecto activador de la resorci\u00f3n por una v\u00eda independiente del rankl.  a pesar de la amplia utilizaci\u00f3n de los aloinjertos \u00f3seos en cirug\u00eda traumatolog\u00eda, no existen apenas trabajos b\u00e1sicos que profundicen en el mecanismos fistiopatol\u00f3gico de lainteracci\u00f3n entre los aloinjertos y las c\u00e9lulas del huesped. Por esta raz\u00f3n, el objetivo de este trabajo ha sido estudiar:  1,- la modulaci\u00f3n de la resorci\u00f3n \u00f3sea ante la presencia del aloinjerto, mediante el an\u00e1lisis de la s\u00edntesis y liberaci\u00f3n por los osteoblastos de la il6, como factor activador de la resorci\u00f3n, y de la opg como factor antiresortivo.  2,- la influencia del aloinjerto sobre la formaci\u00f3n \u00f3sea, analizando directamente la proliferaci\u00f3n osteobl\u00e1stica, y la s\u00edntesis de col\u00e1geno \u00f3seo, principal constituyente de la matriz \u00f3sea, a trv\u00e9s de la medida del pinp.  este estudio se ha realizado utilizando osteoblastos humanos cultivados durante dos semanas, con (problema) o sin (control) la adici\u00f3n de aloinjerto. los aloinjertos fueron obtenidos de cabezas femorales autoclavadas y conservadas a -80\u00c2\u00bac hasta su uso.  los resultados muestran que la presencia de los aloinjertos disminuye la proliferaci\u00f3n de osteoblastos durante la primera semana pero, a partir de la segunda semana, la presencia de los aloinjertos incrementa significativamente la proliferaci\u00f3n de osteoblastos, cuando se compara con su control, sin aloinjerto<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos producidos por la matriz de los aloinjertos sobre las c\u00e9lulas oseas del receptor<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos producidos por la matriz de los aloinjertos sobre las c\u00e9lulas oseas del receptor <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodr\u00edguez De Acu\u00f1a Martinez Lucrecia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Piedra Gordo Concepci\u00f3n De La<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Ruiz amil <\/li>\n<li> Alvarez arroyo Mar\u00eda victoria (vocal)<\/li>\n<li>Manuel D\u00edaz curiel (vocal)<\/li>\n<li> Garcia moreno m. carmen (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodr\u00edguez De Acu\u00f1a Martinez Lucrecia La incorporaci\u00f3n de un aloinjerto \u00f3seo est\u00e1 acompa\u00f1ada de una cascada de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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