{"id":25314,"date":"2003-12-09T00:00:00","date_gmt":"2003-12-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-protea%c2%adnas-quinasas-c-clasicas-y-su-interaccion-con-ligandos-y-membranas\/"},"modified":"2003-12-09T00:00:00","modified_gmt":"2003-12-09T00:00:00","slug":"estudio-de-las-protea%c2%adnas-quinasas-c-clasicas-y-su-interaccion-con-ligandos-y-membranas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/estudio-de-las-protea%c2%adnas-quinasas-c-clasicas-y-su-interaccion-con-ligandos-y-membranas\/","title":{"rendered":"Estudio de las prote\u00ednas quinasas c cl\u00e1sicas  y su interacci\u00f3n con ligandos y membranas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Torrecillas S\u00e1nchez <\/strong><\/h2>\n<p>La prote\u00edna quinasa c (pkc) participa en numerosas funciones fisiol\u00f3gicas a trav\u00e9s de distintas rutas de se\u00f1alizaci\u00f3n celular. El grupo de las isoenzimas cl\u00e1sicas de la pkc incluye a la pkc alfa, beta i, beta ii y gamma y est\u00e1 regulado por diacilglicerol, \u00e9steres de forbol, calcio y fosfol\u00edpidos ani\u00f3nicos.  la introducci\u00f3n de una insaturaci\u00f3n en una de las cadenas de los diacilgliceroles que forman parte de la membrana modifica en gran medida la capacidad de activaci\u00f3n de la pkc alfa de manera independiente a la presencia de fosfol\u00edpidos ani\u00f3nicos y cationes divalentes.  los dominios c2 de las isoenzimas cl\u00e1sicas de la pkc muestran afinidades similares por calcio en ausencia de membranas y el proceso implica la intervenci\u00f3n de la menos dos cationes seg\u00fan los estudios realizados mediante espectrocop\u00eda de fluorescencia. La presencia de membranas aument\u00f3 la afinidad por el cati\u00f3n. Adem\u00e1s, los tres dominios interaccionan de manera distinta con las membranas en presencia de calcio.  seg\u00fan la calorimetr\u00eda de titulaci\u00f3n isot\u00e9rmica, los dominios c2 de las isoenzimas cl\u00e1sicas de la pkc presentan dos tipos de sitios de uni\u00f3n de calcio, para enlazar un total de tres cationes de manera similar. La desnaturalizaci\u00f3n t\u00e9rmica de estos dominios c2 en presencia de distintas concentraciones de calcio fue irreversible. La transici\u00f3n se desplaz\u00f3 hacia mayores temperaturas con concentraciones crecientes de calcio, siendo mayor el efecto en presencia de fosfol\u00edpidos ani\u00f3nicos. El significado de los ligandos unidos a cada uno de los dominios c2 fue diferente.  la estructura secundaria de los dominios c2 de las isoenzimas cl\u00e1sicas de la pkc obtenida mediante espectroscop\u00eda de infrarrojo mostr\u00f3 una elevada proporci\u00f3n de hoja beta. La adici\u00f3n de calcio no modific\u00f3 la estructura secundaria pero s\u00ed aument\u00f3 la estabilidad frente a la desnaturalizaci\u00f3n t\u00e9rmica. El proceso de desnaturalizaci\u00f3n de los dominios c2 fue distin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las prote\u00ednas quinasas c cl\u00e1sicas  y su interacci\u00f3n con ligandos y membranas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las prote\u00ednas quinasas c cl\u00e1sicas  y su interacci\u00f3n con ligandos y membranas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Torrecillas S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> G\u00f3mez Fern\u00e1ndez Juan  Carmelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rodr\u00edguez arrondo Jos\u00e9 Luis <\/li>\n<li>Francisco Fernandez belda (vocal)<\/li>\n<li> Godos de Francisco Ana Mar\u00eda de (vocal)<\/li>\n<li>ignacio Fita rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Torrecillas S\u00e1nchez La prote\u00edna quinasa c (pkc) participa en numerosas funciones fisiol\u00f3gicas a trav\u00e9s de distintas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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