{"id":25387,"date":"2018-03-09T09:16:45","date_gmt":"2018-03-09T09:16:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dihidrotestosterona-bicalutamida-y-hueso-estudio-experimental-en-ratas-macho-y-en-cultivo-primario-de-osteoblastos-humanos\/"},"modified":"2018-03-09T09:16:45","modified_gmt":"2018-03-09T09:16:45","slug":"dihidrotestosterona-bicalutamida-y-hueso-estudio-experimental-en-ratas-macho-y-en-cultivo-primario-de-osteoblastos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/dihidrotestosterona-bicalutamida-y-hueso-estudio-experimental-en-ratas-macho-y-en-cultivo-primario-de-osteoblastos-humanos\/","title":{"rendered":"Dihidrotestosterona, bicalutamida y hueso. estudio experimental en ratas macho y en cultivo primario de osteoblastos humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lefort Cristobal M. Mar <\/strong><\/h2>\n<p>Los efectos fundamentales de los andr\u00f3genos en el hueso son claramente anab\u00f3licos, de forma que facilitan la actividad osteobl\u00e1stica, estimulando la formaci\u00f3n del hueso.  los tratamientos para el c\u00e1ncer de pr\u00f3stata est\u00e1n basados en la deprivaci\u00f3n de andr\u00f3genos circulantes, con el fin de inhibir el crecimiento tumoral.  las drogas antiadrog\u00e9nicas se clasifican en compuestos de tipo esteroideo y no esteroideo. Los antiandr\u00f3genos esteroideos inhiben la uni\u00f3n del andr\u00f3geno al receptor, pero tambi\u00e9n reducen los niveles plasm\u00e1ticos de testosterona, dando lugar a una serie de efectos no deseables: p\u00e9rdida de l\u00edbido, p\u00e9rdida de potencia er\u00e9ctil, ginecomastia, trombosis, etc. Los antiandr\u00f3genos no esteroideos bloquean exclusivamente la uni\u00f3n celular del andr\u00f3geno al receptor y presentan menor cantidad de efectos secundarios. Dentro de este grupo se encuentra el antiandr\u00f3geno bicalutamida, desarrollado recientemente para tratar el carcinoma prost\u00e1sico.  la introducci\u00f3n de antiadr\u00f3genos en el tratamiento de este tipo de c\u00e1ncer lleva a cuesitonarse c\u00f3mo puede influir esta terapia sobre la masa \u00f3sea de estos pacientes.  por lo expuesto anteriormente los objetivos de este trabajo han sido:  * estudiar los efectos producidos por la administraci\u00f3n de bicalutamida a ratas macho compar\u00e1ndolos con los producidos por la castraci\u00f3n, sobre la densidad de mineral \u00f3sea, el remodelado \u00f3seo y las propiedades biomec\u00e1nicas del hueso.  * estudiar los efectos producidos por la dihidrotestosterona y la bicalutamida sobre la proliferaci\u00f3n osteobl\u00e1stica, sobre la s\u00edntesis de matriz \u00f3sea y sobre los niveles de expresi\u00f3n y liberaci\u00f3n en presencia o ausencia de interleuquina 1 de los dos prote\u00ednas liberadas por los osteoblastos y que ejercen su acci\u00f3n sobre los osteoclastos: interleuquina 6 y osteoprotegerina.  se relizaron dos estudios:  * estudio in vivo en ratas macho de 16 semanas de edad que se dividieron en 3 grupos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dihidrotestosterona, bicalutamida y hueso. estudio experimental en ratas macho y en cultivo primario de osteoblastos humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dihidrotestosterona, bicalutamida y hueso. estudio experimental en ratas macho y en cultivo primario de osteoblastos humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lefort Cristobal M. Mar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Piedra Gordo Concepci\u00f3n De La<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Prieto villap\u00fan <\/li>\n<li> Traba villameytide m. Luisa (vocal)<\/li>\n<li>julia Bujan varela (vocal)<\/li>\n<li>Javier Calahorra fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lefort Cristobal M. Mar Los efectos fundamentales de los andr\u00f3genos en el hueso son claramente anab\u00f3licos, de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426],"tags":[74035,17527,14278,74033,25506,74034],"class_list":["post-25387","post","type-post","status-publish","format-standard","hentry","category-alcala","tag-javier-calahorra-fernandez","tag-juan-carlos-prieto-villapun","tag-julia-bujan-varela","tag-lefort-cristobal-m-mar","tag-piedra-gordo-concepcion-de-la","tag-traba-villameytide-m-luisa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25387"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25387\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}