{"id":25419,"date":"2018-03-09T09:16:48","date_gmt":"2018-03-09T09:16:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-mdr1-glutation-s-transferasa-m1-t1-y-p1-y-su-relacion-con-el-riesgo-de-enfermedad-de-parkinson\/"},"modified":"2018-03-09T09:16:48","modified_gmt":"2018-03-09T09:16:48","slug":"polimorfismos-mdr1-glutation-s-transferasa-m1-t1-y-p1-y-su-relacion-con-el-riesgo-de-enfermedad-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/polimorfismos-mdr1-glutation-s-transferasa-m1-t1-y-p1-y-su-relacion-con-el-riesgo-de-enfermedad-de-parkinson\/","title":{"rendered":"Polimorfismos mdr1, glutation s-transferasa m1, t1 y p1 y su relaci\u00f3n con el riesgo de enfermedad de parkinson"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisabet Leiva Badosa <\/strong><\/h2>\n<p>Introducci\u00f3n  la enfermedad de parkinson (ep) es una patolog\u00eda multifactorial en la que intervienen factores ambientales y gen\u00e9ticos. La hip\u00f3tesis ecogen\u00e9tica es la m\u00e1s aceptada y defiende una susceptibilidad interindividual frente a toxinas ambientales, traduci\u00e9ndose en una reducci\u00f3n de la detoxificaci\u00f3n enzim\u00e1tica.  la familia de enzimas glutation s-transferasa (gst) participa en procesos metab\u00f3licos de detoxificaci\u00f3n de xenobi\u00f3ticos y endobi\u00f3ticos.  la glicoprote\u00edna-p, prote\u00edna codificada por el gen mdr1, act\u00faa como una bomba expulsora de m\u00faltiples sustancias al exterior celula confiriendo una protecci\u00f3n espec\u00edfica.  ambas prote\u00ednas estan sujetas a diferencias polim\u00f3rficas individuales, determinando diferentes niveles de expresi\u00f3n y funcionalidad.  objetivo  determinar la influencia de los polimorfismos gstm1, gstt1, gstp1 ile105val y mdr1 c3435t sobre la enfermedad de parkinson, comparando una poblaci\u00f3n sana con una formada por enfermos de parkinson, teniendo en cuenta la edad de aparici\u00f3n de la enfermedad. Adem\u00e1s se evalu\u00f3 la influencia de la exposici\u00f3n a pesticidas sobre la susceptibilidad gen\u00e9tica, mediada por dichos polimorfismos.  material y metodos  estudio caso-control en el que se incluyeron 106 controles sanos y 106 casos enfermos de ep, obtenidos mediante un emparejamiento 1:1 de modo que cada control era el c\u00f3nyuge de un caso.  la determinaci\u00f3n de los genotipos gstm1 y gstt1 se llev\u00f3 a cabo mediante una pcr multiplex, mientras que los genotipos gstp1 y mdr1 se analizaron por rflp-pcr.  tanto los casos como los controles fueron sometidos a una entrevista estructurada en la que se incluyan factores de riesgo para la ep.  conclusiones  1,- el polimorfismo gstm1 con constituyen un factor de riesgo de padecer ep respecto a la poblaci\u00f3n sana, as\u00ed como entre aquella poblaci\u00f3n expuesta a pesticidas.  2,- el polimorfismo gstt1 no constituye un factor de riesgo de padecer ep respec<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos mdr1, glutation s-transferasa m1, t1 y p1 y su relaci\u00f3n con el riesgo de enfermedad de parkinson<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos mdr1, glutation s-transferasa m1, t1 y p1 y su relaci\u00f3n con el riesgo de enfermedad de parkinson <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisabet Leiva Badosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Blanca Sinues Porta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: blanca Conde g\u00ed\u00bcerri <\/li>\n<li>hugo Lia\u00f1o mart\u00ednez (vocal)<\/li>\n<li>jos\u00e9p Traserra parareda (vocal)<\/li>\n<li> Garc\u00eda de jalon comet angel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisabet Leiva Badosa Introducci\u00f3n la enfermedad de parkinson (ep) es una patolog\u00eda multifactorial en la que intervienen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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