{"id":25420,"date":"2018-03-09T09:16:48","date_gmt":"2018-03-09T09:16:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-factores-patogenicos-ambientales-y-geneticos-en-la-hemorragia-digestiva-alta-por-lesiones-pepticas-asociada-a-la-ingesta-cronica-de-aas\/"},"modified":"2018-03-09T09:16:48","modified_gmt":"2018-03-09T09:16:48","slug":"estudio-de-factores-patogenicos-ambientales-y-geneticos-en-la-hemorragia-digestiva-alta-por-lesiones-pepticas-asociada-a-la-ingesta-cronica-de-aas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/zaragoza\/estudio-de-factores-patogenicos-ambientales-y-geneticos-en-la-hemorragia-digestiva-alta-por-lesiones-pepticas-asociada-a-la-ingesta-cronica-de-aas\/","title":{"rendered":"Estudio de factores patog\u00e9nicos ambientales y gen\u00e9ticos en la hemorragia digestiva alta por lesiones p\u00e9pticas, asociada a la ingesta cr\u00f3nica de aas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Fuentes Olmo <\/strong><\/h2>\n<p>Introduccion: en la patogenia de la \u00falcera p\u00e9ptica y de las complicaciones de la misma (perforaci\u00f3n, hemorragia), se ha implicado factores ambientales bien conocidos como la infecci\u00f3n por helicobacter pilory (hp) o el consumo de antiinflamatorios no esteroideos, entre los que se encuentra el \u00e1cido acetil salic\u00edlico (aas).  Tambi\u00e9n ha sido ampliamente estudiada la interacci\u00f3n entre ambos entre ambos con resultados dispares, por lo que se piensa que otros factores, entre ellos algunos determinantes gen\u00e9ticos, tambi\u00e9n parecen desempe\u00f1ar un papel importante.  Entre estos \u00faltimos se ha considerado por su posible implicaci\u00f3n en la complicaci\u00f3n hemorr\u00e1gica, los polimorfismos de los genes que codifican la sintetasa del \u00f3xido n\u00edtrico y la glicoprote\u00edna de adhesi\u00f3n de las plaquetas al fibrin\u00f3geno (glicoprote\u00edna iib\/iiia).  hipotesis: 1.- La infecci\u00f3n por hp aumenta el riesgo de hemorragia digestiva alta en los pacientes que toman aspirina a dos bajas como profilaxis de patolog\u00eda vascular oclusiva. 2.- El riesgo de hemorragia digestiva alta en pacientes que toman aspirina a dosis bajas est\u00e1 asociado a la presencia de determinantes gen\u00e9ticos dependientes de los genes de la \u00f3xido n\u00edtrico sintetasa y del receptor plaquetario de la glicoprote\u00edna iib\/iiia.  objetivos: objetivos primarios: 1.- Establecer el riesgo de hemorragia digestiva alta asociada a la infecci\u00f3n por hp en pacientes con patolog\u00eda cardiovascular que toman aspirina a dosis bajas. 2.- Determinan la asociaci\u00f3n de polimorfismos gen\u00e9ticos de sintasa del no y de la glicoprote\u00edna iib\/iiia con el riesgo de sufrir hemorragia digestiva alta por lesiones p\u00e9pticas en pacientes con patolog\u00eda cardiovascular que toman aspirina a dosis bajas.  objetivos secundarios: 1.- Analizar si algunos determinantes de patogenicidad de  hp (caga y vaca) se asocian con n riesgo mayor de hemorragia digestiva alta en los pacientes que toman aspirina a dosis profil\u00e1cticas. 2.- Analiz<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de factores patog\u00e9nicos ambientales y gen\u00e9ticos en la hemorragia digestiva alta por lesiones p\u00e9pticas, asociada a la ingesta cr\u00f3nica de aas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de factores patog\u00e9nicos ambientales y gen\u00e9ticos en la hemorragia digestiva alta por lesiones p\u00e9pticas, asociada a la ingesta cr\u00f3nica de aas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Fuentes Olmo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Lanas Arbeloa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Sainz samitier <\/li>\n<li>Fernando Borda celaya (vocal)<\/li>\n<li>Juan  ignacio Arenas mirave (vocal)<\/li>\n<li>Rafael Benito ruesca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Fuentes Olmo Introduccion: en la patogenia de la \u00falcera p\u00e9ptica y de las complicaciones de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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