{"id":25468,"date":"2018-03-09T09:16:52","date_gmt":"2018-03-09T09:16:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-y-cineticas-de-adsorcion-liberacion-de-farmacos-en-soporte-arcilloso-contribucion-al-estudio-de-complejos-timolol-maleato-con-esmectitas-paligorskitas-y-sepiolitas\/"},"modified":"2018-03-09T09:16:52","modified_gmt":"2018-03-09T09:16:52","slug":"mecanismos-y-cineticas-de-adsorcion-liberacion-de-farmacos-en-soporte-arcilloso-contribucion-al-estudio-de-complejos-timolol-maleato-con-esmectitas-paligorskitas-y-sepiolitas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-y-cineticas-de-adsorcion-liberacion-de-farmacos-en-soporte-arcilloso-contribucion-al-estudio-de-complejos-timolol-maleato-con-esmectitas-paligorskitas-y-sepiolitas\/","title":{"rendered":"Mecanismos y cin\u00e9ticas de adsorci\u00f3n-liberaci\u00f3n de f\u00e1rmacos en soporte arcilloso, contribuci\u00f3n al estudio de complejos timolol maleato con esmectitas, paligorskitas y sepiolitas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Pilar Cerezo Gonzalez <\/strong><\/h2>\n<p>Se han estudiado complejos formados por diversas arcillas (de yacimiento y comercializadas) y el f\u00e1rmaco timolol (antagonista beta-adren\u00e9rgico no selectivo) utilizado por v\u00eda oral como antihipertensivo y\/o antianginoso con la finalidad de desarrollar formas farmac\u00e9uticas de liberaci\u00f3n modificada (controlada), hasta ahora, no disponibles en el mercado farmac\u00e9utico.  el f\u00e1rmaco, de acuerdo con su perfil farmacocin\u00e9tico y propiedades f\u00edsico-qu\u00edmicas, se mostr\u00f3 como candidato ideal, por lo que en estudio previo de preformulaci\u00f3n se procedi\u00f3 a la tipificaci\u00f3n de sus caracter\u00edsticas f\u00edsicas, textuales y de estabilidad en los medios de disoluci\u00f3n que posteriormente se emplearon en el estudio de disoluci\u00f3n; de igual manera, se caracterizaron las arcillas (3 bentonitas, 3 paligorskitas y 2 sepiolitas) desde el punto de vista de su composici\u00f3n f\u00edsica, propiedades qu\u00edmicas, comportamiento t\u00e9rmico y estabilidad, mediante una variedad de t\u00e9cnicas que abarcan desde los espectros uv-v, ir, rayos x, punto de fusi\u00f3n, ph, microscop\u00eda electr\u00f3nica de barridos, an\u00e1lisis granulom\u00e9trico de rayo l\u00e1ser y porosimetr\u00eda de mercurio, a algunos de los ensayos farmacot\u00e9cnicos recogios en la rfe, tales como evaluaci\u00f3n porosim\u00e9trica, volumen aparente, densidad, etc. Asimismo, se comprob\u00f3 experimentalmente la compatibilidad del f\u00e1rmaco al estado s\u00f3lido en mezclas f\u00edsicas con las arcillas, en funci\u00f3n de la temperatura y tiempo de tratamiento, mediante calorimetr\u00eda diferencial de barrido (dsc).  previos ensayos de orientaci\u00f3n, se procedi\u00f3 al estudio de los factores influyentes en la formaci\u00f3n de los complejos: temperatura de tratamiento previo de la arcilla (con vistas a su activaci\u00f3n), concentraci\u00f3n del f\u00e1rmaco en la soluci\u00f3n y tiempo de contacto de la soluci\u00f3n f\u00e1rmaco-arcilla, aplicando la t\u00e9cnica de dise\u00f1o de diagn\u00f3stico experimental y optimizaci\u00f3n (factorial 2 3).  el citado estudio permiti\u00f3 establecer las condicion<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos y cin\u00e9ticas de adsorci\u00f3n-liberaci\u00f3n de f\u00e1rmacos en soporte arcilloso, contribuci\u00f3n al estudio de complejos timolol maleato con esmectitas, paligorskitas y sepiolitas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos y cin\u00e9ticas de adsorci\u00f3n-liberaci\u00f3n de f\u00e1rmacos en soporte arcilloso, contribuci\u00f3n al estudio de complejos timolol maleato con esmectitas, paligorskitas y sepiolitas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Pilar Cerezo Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Cerezo Galan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep m. Su\u00f1e arbussa <\/li>\n<li>eugenio Selles florez (vocal)<\/li>\n<li>Manuel Rodr\u00edguez gallego (vocal)<\/li>\n<li>isam Ismail salem (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Pilar Cerezo Gonzalez Se han estudiado complejos formados por diversas arcillas (de yacimiento y comercializadas) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[33532,74203,74204,362,4220,74202],"class_list":["post-25468","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-cerezo-galan","tag-eugenio-selles-florez","tag-isam-ismail-salem","tag-josep-m-sune-arbussa","tag-manuel-rodriguez-gallego","tag-maria-pilar-cerezo-gonzalez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25468"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25468\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}