{"id":25496,"date":"2018-03-09T09:16:55","date_gmt":"2018-03-09T09:16:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-molecular-del-proceso-de-envejecimiento-de-linfocitos-t-y-celulas-nk\/"},"modified":"2018-03-09T09:16:55","modified_gmt":"2018-03-09T09:16:55","slug":"estudio-molecular-del-proceso-de-envejecimiento-de-linfocitos-t-y-celulas-nk","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/estudio-molecular-del-proceso-de-envejecimiento-de-linfocitos-t-y-celulas-nk\/","title":{"rendered":"Estudio molecular del proceso de envejecimiento de linfocitos t y celulas nk"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Duro Llamas Francisco Jose <\/strong><\/h2>\n<p>El n\u00famero de c\u00e9lulas nk se encuentra incrementado en ancianos sanos, cuando se comparan con los valores encontrados en jovenes, tanto en valores absolutos como porcentuales. Ese aumento es debido a la expansi\u00f3n de las celulas nk cd56 dim, que representan las celulas con mayor capacidad citotoxica y menor capacidad proliferativa y de producci\u00f3n de citocinas.  el estudio de la capacidad de respuesta de las celulas nk de ancianos a il-2 nos muestra que tanto la proliferaci\u00f3n como la inducci\u00f3n de cd-69 se encuentran descendidas. Contrariamente el tratamiento con il-2 de \u00f1as ce\u00f1i\u00f1as nk procedentes de ancianos induce una liberaci\u00f3n de tnf-alfa similar a lo observado en individuos jovenes. El flujo de calcio en respuesta a la il-2 se encuentra descendido en las c\u00e9lulas nk de ancianos en comparaci\u00f3n con las celulas nk de individuos jovenes.  en ancianos existe un aumento significativo del porcentaje de c\u00e9lulas t que expresan marcadores asociados a c\u00e9lulas nk, cd56, cd57, cd94, as\u00ed como un aumeno del porcentaje de linfocitos t que no expresan cd28 y que poseen la isoforma cd45ro. El proceso de envejecimiento se asocia a la expansi\u00f3n tanto en c\u00e9lulas nk con caracter\u00edsticas de c\u00e9lulas activadas como a la expansi\u00f3n de linofocitos t que coeexpresan marcadores nk. Estas c\u00e9lulas podr\u00edan desempe\u00f1ar un papel compensador frente a las alteraciones cuantitativas y funcionales definidas en los linfocitos t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio molecular del proceso de envejecimiento de linfocitos t y celulas nk<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio molecular del proceso de envejecimiento de linfocitos t y celulas nk <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Duro Llamas Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Solana Lara<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li>Ana beatriz Rodr\u00edguez  moratinos (vocal)<\/li>\n<li>julia Carracedo a\u00f1on (vocal)<\/li>\n<li>eduardo Ortega rinc\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Duro Llamas Francisco Jose El n\u00famero de c\u00e9lulas nk se encuentra incrementado en ancianos sanos, cuando se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,1737],"tags":[59616,74257,19510,13,44697,3760],"class_list":["post-25496","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-inmunologia","tag-ana-beatriz-rodriguez-moratinos","tag-duro-llamas-francisco-jose","tag-eduardo-ortega-rincon","tag-jose-pena-Martinez","tag-julia-carracedo-anon","tag-rafael-solana-lara"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25496","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25496"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25496\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25496"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25496"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}