{"id":25498,"date":"2018-03-09T09:16:55","date_gmt":"2018-03-09T09:16:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/design-synthesis-biological-evaluation-and-structural-studies-of-1-alfa-25-dihydroxyvitamin-d3-analogs-modified-at-c12\/"},"modified":"2018-03-09T09:16:55","modified_gmt":"2018-03-09T09:16:55","slug":"design-synthesis-biological-evaluation-and-structural-studies-of-1-alfa-25-dihydroxyvitamin-d3-analogs-modified-at-c12","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/design-synthesis-biological-evaluation-and-structural-studies-of-1-alfa-25-dihydroxyvitamin-d3-analogs-modified-at-c12\/","title":{"rendered":"Design, synthesis, biological evaluation, and structural studies of 1-alfa, 25-dihydroxyvitamin d3 analogs modified at c12"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez Avi\u00f3n Xos\u00e9 Carlos <\/strong><\/h2>\n<p>La forma activa de la vitamina d (la hormona 1alfa,25-dihidroxivitamina d3, 1) regula el metabolismo del calcio y del f\u00f3sforo, y adem\u00e1s tiene efectos antiproliferativos y prodiferenciadores. Por estos motivos, alrededor de 3000 an\u00e1logos de esta hormona han sido sintetizados y su potencial farmacol\u00f3gico evaluado con el fin de identificar f\u00e1rmacos selectivos de potencial utilidad para el tratamiento del c\u00e1ncer y enfermedades relacionadas, pero que no trastornen el metabolismo del calcio. Sin embargo, ning\u00fan an\u00e1logo conocido hasta hoy presentaba modificaciones en la posici\u00f3n c-12 de la hormona.  en presente trabajo de tesis doctoral se sintetiz\u00f3 una serie completa de an\u00e1logos de la hormona 1alfa, 25-dihidroxivitamina d3 con distintos sustituyentes en la posici\u00f3n c12 (an\u00e1logos 4a-e) y se analizaron ciertos aspectos de su actividad biol\u00f3gica en comparaci\u00f3n con la actividad de la hormona natural. Tambi\u00e9n se dise\u00f1\u00f3, y evalu\u00f3 biol\u00f3gicamente una serie de an\u00e1logos con la cadena lateral unida a la posici\u00f3n c12 (an\u00e1logos 5a-c). finalmente, se determin\u00f3, mediante cristalograf\u00eda de rayos x, la estructura cristalina del an\u00e1logo 5b unido al receptor de la hormona 1alfa, 25-dihidroxivitamina d3.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Design, synthesis, biological evaluation, and structural studies of 1-alfa, 25-dihydroxyvitamin d3 analogs modified at c12<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Design, synthesis, biological evaluation, and structural studies of 1-alfa, 25-dihydroxyvitamin d3 analogs modified at c12 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez Avi\u00f3n Xos\u00e9 Carlos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mouri\u00f1o Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: claudio Palomo nicolau <\/li>\n<li>carsten Carlberg (vocal)<\/li>\n<li>natacha Rochel (vocal)<\/li>\n<li> Soares da silva artur Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez Avi\u00f3n Xos\u00e9 Carlos La forma activa de la vitamina d (la hormona 1alfa,25-dihidroxivitamina d3, 1) regula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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