{"id":25530,"date":"2018-03-09T09:16:57","date_gmt":"2018-03-09T09:16:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectividad-versus-toxicidad-del-minoxidil-como-agente-antiproliferativo-de-celulas-epiteliales-del-cristalino-estudio-in-vitro\/"},"modified":"2018-03-09T09:16:57","modified_gmt":"2018-03-09T09:16:57","slug":"efectividad-versus-toxicidad-del-minoxidil-como-agente-antiproliferativo-de-celulas-epiteliales-del-cristalino-estudio-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/efectividad-versus-toxicidad-del-minoxidil-como-agente-antiproliferativo-de-celulas-epiteliales-del-cristalino-estudio-in-vitro\/","title":{"rendered":"Efectividad versus toxicidad del minoxidil como agente antiproliferativo de c\u00e9lulas epiteliales del cristalino. estudio in vitro"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Urrutia Rodr\u00edguez Manuel Alberto <\/strong><\/h2>\n<p>La opacificaci\u00f3n capsular posterior constituye la complicaci\u00f3n postoperatoria tard\u00eda m\u00e1s frecuente en los pacientes intervenidos de catarata, representando un problema importante en cirug\u00eda ocular. Las modificaciones introducidas sobre lat\u00e9cnica quir\u00fargica y las lentes intraoculares han permitido reducir notablemente su incidencia, seg\u00fan los resultados publicados en estudios retrospectivos, aunque en las cataratas infantiles y en los paises en v\u00edas de desarrollo sigue siendo un problema frecuente. Los ensayos experimentales realizados in vitro sobre cultivos monocapas de c\u00e9lulas epiteliales de cristalino han abierto un campo de investigaci\u00f3n para la b\u00fasqueda de f\u00e1rmacos que, empleados en el acto quir\u00fargico y durante el postoperatorio, quedan reducir los \u00edndices de opacifiaci\u00f3n capsular. El minoxidil ha demostrado un efecto antiproliferativo in vitro sobre determinadas estirpes celulares seg\u00fan diversos trabajos publicados en la d\u00e9cada de los 90, lo que nos ha llevado a analizar su efecto sobre c\u00e9lulas epiteliales de cristalino, as\u00ed como su toxicidad sobre c\u00e9lulas endoteliales corneales en el presente trabajo, utilizando como modelo animal el conejo albino de la raza new zealand.  los resultados obtenidos en nuestro estudio demuestran que el minoxidil ejerce un efecto inhibidor\/lesivo sobre ambos tipos celulares, siendo m\u00e1s significativo en los cultivos de c\u00e9lulas endoteliales (69,35% frente a 32,28% en c\u00e9lulas epiteliales), lo que constituye un efecto t\u00f3xico relevante que le hace poco id\u00f3neo para ser considerado en posteriores estudios de cara a su aplicaci\u00f3n cl\u00ednica en cirug\u00eda ocular, sobre el tratamiento y prevenci\u00f3n de la opacificaci\u00f3n capsular posterior.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectividad versus toxicidad del minoxidil como agente antiproliferativo de c\u00e9lulas epiteliales del cristalino. estudio in vitro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectividad versus toxicidad del minoxidil como agente antiproliferativo de c\u00e9lulas epiteliales del cristalino. estudio in vitro <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Urrutia Rodr\u00edguez Manuel Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emiliano Hern\u00e1ndez Galilea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Bullon sopelana <\/li>\n<li> Herrera contalapiedra Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>teresa Rodr\u00edguez Mar\u00eda (vocal)<\/li>\n<li>Juan  Luis G\u00f3mez gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Urrutia Rodr\u00edguez Manuel Alberto La opacificaci\u00f3n capsular posterior constituye la complicaci\u00f3n postoperatoria tard\u00eda m\u00e1s frecuente en los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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