{"id":25566,"date":"2018-03-09T09:17:00","date_gmt":"2018-03-09T09:17:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-celulares-y-moleculares-inducidos-a-nivel-cardiaco-tras-la-administracion-cronica-de-opioides\/"},"modified":"2018-03-09T09:17:00","modified_gmt":"2018-03-09T09:17:00","slug":"cambios-celulares-y-moleculares-inducidos-a-nivel-cardiaco-tras-la-administracion-cronica-de-opioides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/cambios-celulares-y-moleculares-inducidos-a-nivel-cardiaco-tras-la-administracion-cronica-de-opioides\/","title":{"rendered":"Cambios celulares y moleculares inducidos a nivel cardiaco tras la administraci\u00f3n cr\u00f3nica de opioides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M. Gonz\u00e1lez Cuello <\/strong><\/h2>\n<p>El t\u00e9rmino farmacodependencia o adicci\u00f3n indica la p\u00e9rdida del control sobre el uso de una sustancia. Entre las sustancias con mayor poder adictivo se encuentran los opioides como la morfina y sus derivados. La administraci\u00f3n cr\u00f3nica de morfina produce un estado de tolerancia caracterizado por una serie de cambios neuroadaptativos que conducen a una disminuci\u00f3n progresiva de efecto a medida que la sustancia se consume reiteradamente. La dependencia consiste en un trastorno conductual, psicol\u00f3gico, bioqu\u00edmico y molecular por el que el individuo tiene disminuido el control sobre el consumo de una droga.  la mayor\u00eda de estudios de tolerancia\/dependencia se han realizado en snc, existiendo en la actualidad un gran desconocimiento de los mecanismos responsables de estos fen\u00f3menos a nivel cardiaco.  nuestro objetivo global fue contribuir a esclarecer algunos de los mecanismos celulares y moleculares que subyacen en la modificaciones cardiacas que se producen durante el s\u00edndrome de abstinencia a opioides.  para ello estudiamos el recambio de noradrenalina en coraz\u00f3n durante el s\u00edndrome de abstinencia a morfina tras la administraci\u00f3n de naloxona, as\u00ed como, tras la administraci\u00f3n del derivado cuaternario naloxona metil yoduro (nxm) con el objeto de averiguar si la hiperactividad noradren\u00e9rgica observada durante el s\u00edndrome de abstinencia era debida a mecanismos perif\u00e9ricos independientes del snc.  el an\u00e1lisis de na y sus metabolitos se realiz\u00f3 mediante hplc. Los resultados mostraron que la activaci\u00f3n cr\u00f3nica del receptor opioide produc\u00eda una serie de fen\u00f3menos adaptativos compensatorios en las neuronas noradren\u00e9rgicas cardiacas, que dar\u00edan lugar a cambios en la s\u00edntesis y\/o liberaci\u00f3n de na, procesos que quedan desenmascarados durante el s\u00edndrome de abstinencia a morfina. Adem\u00e1s demostramos que esta hiperactividad noradren\u00e9rgica, era debida a mecanismos perif\u00e9ricos indpendientes del snc.  a continuaci\u00f3n estud<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios celulares y moleculares inducidos a nivel cardiaco tras la administraci\u00f3n cr\u00f3nica de opioides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios celulares y moleculares inducidos a nivel cardiaco tras la administraci\u00f3n cr\u00f3nica de opioides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M. Gonz\u00e1lez Cuello <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Luisa Laorden Carrasco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Ballesta germ\u00e1n <\/li>\n<li>Jos\u00e9 Manuel Baeyens cabrera (vocal)<\/li>\n<li>margarita Puig riera (vocal)<\/li>\n<li>esperanza Del pozo gavil\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M. Gonz\u00e1lez Cuello El t\u00e9rmino farmacodependencia o adicci\u00f3n indica la p\u00e9rdida del control sobre el uso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8235],"tags":[74416,65553,8789,13221,74417,8548],"class_list":["post-25566","post","type-post","status-publish","format-standard","hentry","category-murcia","tag-ana-m-gonzalez-cuello","tag-esperanza-del-pozo-gavilan","tag-jose-ballesta-german","tag-jose-manuel-baeyens-cabrera","tag-margarita-puig-riera","tag-maria-luisa-laorden-carrasco"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25566"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25566\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}