{"id":25609,"date":"2018-03-09T09:17:03","date_gmt":"2018-03-09T09:17:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-expresion-genica-de-clusterina-y-bcl-2-en-la-carcinogenesis-y-progresion-del-cancer-de-mama\/"},"modified":"2018-03-09T09:17:03","modified_gmt":"2018-03-09T09:17:03","slug":"estudio-de-la-expresion-genica-de-clusterina-y-bcl-2-en-la-carcinogenesis-y-progresion-del-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/estudio-de-la-expresion-genica-de-clusterina-y-bcl-2-en-la-carcinogenesis-y-progresion-del-cancer-de-mama\/","title":{"rendered":"Estudio de la expresi\u00f3n g\u00e9nica de clusterina y bcl-2 en la carcinog\u00e9nesis y progresi\u00f3n del c\u00e1ncer de mama"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Villar Alvarez <\/strong><\/h2>\n<p>Hemos determinado la expresi\u00f3n de clusterina y bcl-2 junto al \u00edndice apopt\u00f3tico en una muestra de 116 carcinomas infiltrantes de mama as\u00ed como en muestras de mama de: tejido normal, lesiones benignas, hiperplasias intraductales at\u00edpicas y carcinomas intraductales. Y la hemos puesto en relaci\u00f3n con la carcinog\u00e9nesis, la progresi\u00f3n tumoral y una serie de factores pron\u00f3sticos de categor\u00eda i en el c\u00e1ncer de mama.  en el estudio se han utilizado t\u00e9cnicas de inmunohistoqu\u00edmica convencional, t\u00e9cnica de tunel y de hibridaci\u00f3n \u00abin situ\u00bb.  nuestras conclusiones han sido las siguientes:  1,- un aumento de la expresi\u00f3n de la prote\u00edna clusterina, est\u00e1 asociado con las primeras fases del desarrollo del carcinoma mamario, as\u00ed como con la progresi\u00f3n metast\u00e1sica de estos carcinomas.  2,- la expresi\u00f3n g\u00e9nica de clusterina no es un requisito para el desarrollo de la muerte celular programada. De hecho, su expresi\u00f3n es m\u00e1s frecuente en aquellos carcinomas de mama que presentan una menor actividad apopt\u00f3tica.  3,- bcl-2 es un gen regulado hormonalmente, cuyos cambios en la expresi\u00f3n pueden influir en la adquisici\u00f3n de un fenotipo maligno en el c\u00e1ncer de mama.  4,- un aumento en la actividad apopt\u00f3tica, est\u00e1 relacionado tanto con la capacidad de invasi\u00f3n del carcinoma primario, como con la progresi\u00f3n metast\u00e1sica del c\u00e1ncer de mama.  5,- la disminuci\u00f3n en la expresi\u00f3n de bcl-2 y el aumento de la actividad apopt\u00f3tica, son indicadores de una disminuci\u00f3n de la supervivencia libre de enfermedad, aunque \u00fanicamente el valor del \u00edndice apopt\u00f3tico puede ser considerado un factor pron\u00f3stico independiente.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la expresi\u00f3n g\u00e9nica de clusterina y bcl-2 en la carcinog\u00e9nesis y progresi\u00f3n del c\u00e1ncer de mama<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la expresi\u00f3n g\u00e9nica de clusterina y bcl-2 en la carcinog\u00e9nesis y progresi\u00f3n del c\u00e1ncer de mama <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Villar Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00e1ximino Redondo Bautista<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guzm\u00e1n Ortu\u00f1o pacheco <\/li>\n<li>Jos\u00e9 Miguel Fernandez fernandez (vocal)<\/li>\n<li>Jos\u00e9 ram\u00f3n Armas padr\u00f3n (vocal)<\/li>\n<li> Gonz\u00e1lez de gor ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Villar Alvarez Hemos determinado la expresi\u00f3n de clusterina y bcl-2 junto al \u00edndice apopt\u00f3tico en una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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