{"id":25620,"date":"2018-03-09T09:17:04","date_gmt":"2018-03-09T09:17:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-enantiodivergente-de-pirrolo21-alfaisoquinolinas-basada-en-reacciones-de-alfa-amidoalquilacion-ciclacion-parham-y-adicion-conjugada-estereoselectivas\/"},"modified":"2018-03-09T09:17:04","modified_gmt":"2018-03-09T09:17:04","slug":"sa%c2%adntesis-enantiodivergente-de-pirrolo21-alfaisoquinolinas-basada-en-reacciones-de-alfa-amidoalquilacion-ciclacion-parham-y-adicion-conjugada-estereoselectivas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/pais-vasco-euskal-herriko-unibertsitatea\/sa%c2%adntesis-enantiodivergente-de-pirrolo21-alfaisoquinolinas-basada-en-reacciones-de-alfa-amidoalquilacion-ciclacion-parham-y-adicion-conjugada-estereoselectivas\/","title":{"rendered":"S\u00edntesis enantiodivergente de pirrolo[2,1-alfa]isoquinolinas basada en reacciones de alfa-amidoalquilaci\u00f3n, ciclaci\u00f3n parham y adici\u00f3n conjugada estereoselectivas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> In\u00e9s Gonz\u00e1lez Temprano <\/strong><\/h2>\n<p>En este trabajo de investigaci\u00f3n se han aplicado las secuencias adici\u00f3n nucle\u00f3fila-ciclaci\u00f3n via iones n-aciliminio y ciclaci\u00f3n parham-alfa-amidoalquilaci\u00f3n intermolecular a la preparaci\u00f3n de metanoisoindolinisoquinolinas 12b sustituidas y dihidropirrolo[2,1-alfa]isoquinolinas 10b sustituidas de elevada pureza enantiom\u00e9rica, partiendo de una 2,3-norbornendicarboxiimida que incorpora como auxiliar quiral un resto de 2-exo-hidroxi-10-bornilsulfinilo.  de esta forma, se han desarrollado v\u00edas diastereo y enantiodivergentes de los mencionados heterociclos.  por otra parte, se ha llevado a cabo un estudio del comportamiento de la unidad tact\u00e1mica alfa,beta-insaturada de las dihidropirrolo[2,1-alfa]isoquinolinas 10b sustituidas, en adiciones conjugadas de reactivos organomet\u00e1licos, lo que ha permitido poner a punto una nueva aproximaci\u00f3n a 1,10b tetrahidropirrolo[2,1-alfa]isoquinolinas enantiom\u00e9ricamente enriquecidas. El estudio de la estereoselectividad de estas reacciones de adici\u00f3n conjugada ha revelado que siempre conducen a diastereois\u00f3mero est\u00e9ricamente menos congestionado, en un proceso de control termodin\u00e1mico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis enantiodivergente de pirrolo[2,1-alfa]isoquinolinas basada en reacciones de alfa-amidoalquilaci\u00f3n, ciclaci\u00f3n parham y adici\u00f3n conjugada estereoselectivas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis enantiodivergente de pirrolo[2,1-alfa]isoquinolinas basada en reacciones de alfa-amidoalquilaci\u00f3n, ciclaci\u00f3n parham y adici\u00f3n conjugada estereoselectivas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 In\u00e9s Gonz\u00e1lez Temprano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/09\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther Lete Exp\u00f3sito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Suau suarez <\/li>\n<li>joan Bonjoch ses\u00e9 (vocal)<\/li>\n<li>benito Alcaide (vocal)<\/li>\n<li> Peregria Garc\u00eda Jes\u00fas m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de In\u00e9s Gonz\u00e1lez Temprano En este trabajo de investigaci\u00f3n se han aplicado las secuencias adici\u00f3n nucle\u00f3fila-ciclaci\u00f3n via iones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12909],"tags":[74541,41590,74539,74540,74542,2512],"class_list":["post-25620","post","type-post","status-publish","format-standard","hentry","category-pais-vasco-euskal-herriko-unibertsitatea","tag-benito-alcaide","tag-esther-lete-exposito","tag-ines-gonzalez-temprano","tag-joan-bonjoch-sese","tag-peregria-garcia-jesus-m","tag-rafael-suau-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=25620"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/25620\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=25620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=25620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=25620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}